{"id":"W2744320025","doi":"10.1016/s2468-1253(17)30163-2","title":"Safety and efficacy of a fixed-dose combination regimen of grazoprevir, ruzasvir, and uprifosbuvir with or without ribavirin in participants with and without cirrhosis with chronic hepatitis C virus genotype 1, 2, or 3 infection (C-CREST-1 and C-CREST-2, part B): two randomised, phase 2, open-label trials","year":2017,"lang":"en","type":"article","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Ribavirin; Regimen; Cirrhosis; Internal medicine; Gastroenterology; Hepatitis C virus; Virology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001790769,0.001276968,0.00277264,0.0004604816,0.0003099683,0.000800978,0.00104292,0.001709605,0.004444064],"category_scores_gemma":[0.002141948,0.0008786002,0.001835584,0.0003574513,0.001118515,0.001180546,0.0003612994,0.002531658,0.0008597461],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008337212,"about_ca_system_score_gemma":0.000565329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001182689,"about_ca_topic_score_gemma":0.002135909,"domain_scores_codex":[0.99884,0.000643007,0.00008112731,0.0002192695,0.00008662344,0.0001300375],"domain_scores_gemma":[0.9991307,0.0002695299,0.0002251013,0.00009034677,0.0000602062,0.0002242333],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9631212,0.003176913,0.0008912418,0.0007357431,0.0014848,0.00002784092,0.00007261032,0.0003582965,0.003306146,0.00007256982,0.0003645553,0.02638815],"study_design_scores_gemma":[0.8888826,0.1043661,0.00384237,0.00007235196,0.001115947,0.00006758051,0.00004138965,0.0004589991,0.0004872179,0.000144603,0.0004929841,0.00002798783],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897937,0.006790802,0.0004104458,0.0003286897,0.0002230058,0.0006798804,0.0004261785,0.00008080447,0.001266599],"genre_scores_gemma":[0.9953753,0.00169413,0.0007967034,0.0002960965,0.0001196079,0.0006167568,0.0003371566,0.00001136559,0.000752882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004444064,"threshold_uncertainty_score":0.01486689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1018138454322363,"score_gpt":0.4083181830519395,"score_spread":0.3065043376197032,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}