{"id":"W2744658081","doi":"10.1038/nrcardio.2017.115","title":"HDL and atherosclerotic cardiovascular disease: genetic insights into complex biology","year":2017,"lang":"en","type":"review","venue":"Nature Reviews Cardiology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":152,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Montreal Heart Institute; Université de Montréal","funders":"Icahn School of Medicine at Mount Sinai","keywords":"Mendelian randomization; Genome-wide association study; Disease; Genetic association; Cholesterylester transfer protein; Computational biology; Bioinformatics; Causality (physics); Medicine; Genetics; Complex disease; Biology; Genetic variants; Single-nucleotide polymorphism; Gene; Cholesterol; Genotype; Internal medicine; Lipoprotein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001553257,0.001066507,0.00169251,0.001679754,0.0002737204,0.001405154,0.001114274,0.001916994,0.002306889],"category_scores_gemma":[0.002300069,0.0002989529,0.000516121,0.001919253,0.001055088,0.001751719,0.001270157,0.00299681,0.001077735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007416925,"about_ca_system_score_gemma":0.001946529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001492235,"about_ca_topic_score_gemma":0.002417104,"domain_scores_codex":[0.999638,0.00007436552,0.00004729161,0.00006731031,0.0001417532,0.00003125775],"domain_scores_gemma":[0.9987893,0.0007128898,0.0001032808,0.00003588827,0.0002640977,0.00009463571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001088562,0.00005480467,0.0006640713,0.007692529,0.0001881333,0.0002827428,0.00006057617,0.0004027765,0.001092509,0.00725099,0.04719174,0.9350103],"study_design_scores_gemma":[0.00005253945,0.00006826087,0.002042776,0.005278608,0.0003223841,0.00151642,0.000127639,0.0002371623,0.0003519008,0.01419031,0.9757621,0.00004997144],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006611706,0.9978231,0.0002446876,0.001165404,0.0003510525,0.000002342089,0.00001539412,0.000007646937,0.0003242317],"genre_scores_gemma":[0.0004938873,0.9978009,0.0001980926,0.0005884644,0.0006758176,0.000003550269,0.00002018601,0.000001264736,0.0002178352],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002306889,"threshold_uncertainty_score":0.008214474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07976258704790472,"score_gpt":0.37002591587474,"score_spread":0.2902633288268353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}