{"id":"W2744758186","doi":"10.1158/2159-8290.cd-17-0037","title":"Notch Shapes the Innate Immunophenotype in Breast Cancer","year":2017,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Notch signaling pathway; CCL2; Proinflammatory cytokine; Tumor microenvironment; Cancer research; Medicine; Cancer; Immunology; Biology; Chemokine; Inflammation; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002331447,0.000247359,0.0002999348,0.00005672314,0.0006378606,0.0001710836,0.001203178,0.0001983457,0.001595747],"category_scores_gemma":[0.00003038788,0.0001747919,0.000104469,0.00008859103,0.0006921951,0.0004535878,0.0004146553,0.0005280885,0.0002302672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002388093,"about_ca_system_score_gemma":0.0003362394,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009117967,"about_ca_topic_score_gemma":0.001922004,"domain_scores_codex":[0.9986344,0.00009775542,0.0002850283,0.0003963461,0.00005653759,0.0005299147],"domain_scores_gemma":[0.9986966,0.000065762,0.0002531522,0.0009060871,0.00006588935,0.00001252334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001567538,0.0001950867,0.2114018,0.0001057729,0.0007148862,0.00002104779,0.001853059,0.0007828951,0.6828885,0.001832559,0.03767271,0.06096417],"study_design_scores_gemma":[0.001912141,0.00002438552,0.8895307,0.0003062803,0.00006433115,0.00002276733,0.0002146647,0.00001238612,0.03769194,0.0003123185,0.06946321,0.0004448654],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9376872,0.04402971,0.00001129669,0.007457488,0.0065955,0.0003455858,0.0003082833,0.00003528443,0.003529652],"genre_scores_gemma":[0.9786453,0.006040836,0.00000304106,0.001005266,0.0002230909,0.0002925651,0.00001417254,0.0000384336,0.01373724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.678129,"threshold_uncertainty_score":0.9993169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01467743783043528,"score_gpt":0.2770398972296483,"score_spread":0.262362459399213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}