{"id":"W2744900448","doi":"10.1038/s41598-017-08315-0","title":"Ectodomain shedding of Limbic System-Associated Membrane Protein (LSAMP) by ADAM Metallopeptidases promotes neurite outgrowth in DRG neurons","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Ectodomain; ADAM10; Neurite; Cell biology; Immunoglobulin superfamily; Biology; Metalloproteinase; Dorsal root ganglion; Cell adhesion; Population; Embryonic stem cell; Cell; Disintegrin; Cell adhesion molecule; Neuroscience; Matrix metalloproteinase; Receptor; In vitro; Genetics; Spinal cord; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001218055,0.000242371,0.0002491465,0.0001562798,0.00009845045,0.0001976583,0.0001069548,0.0001540994,0.0005021821],"category_scores_gemma":[0.00009306204,0.00009456969,0.0002791502,0.0001028282,0.0001514105,0.0001619854,0.0002129255,0.0004913011,0.0002448086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003120774,"about_ca_system_score_gemma":0.0002072786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005788049,"about_ca_topic_score_gemma":0.001150482,"domain_scores_codex":[0.9999033,0.00001580979,0.00001295158,0.00001506004,0.00002377194,0.0000290721],"domain_scores_gemma":[0.9999201,0.00001347647,0.00001833197,0.000009444989,0.000007698857,0.00003082807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006480711,0.00001526018,0.0001448523,0.00001681809,0.000002391821,0.00005751544,0.000008611414,0.0000222729,0.9992729,0.00001333366,0.00001274677,0.0003685226],"study_design_scores_gemma":[0.00001893398,0.000533774,0.0163222,0.000009525183,0.0000172116,0.0005222379,0.0000537514,0.0007569705,0.9807441,0.00004465779,0.0009726157,0.000004081448],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978452,0.0008634084,0.0006054536,0.00003124904,0.000009480182,0.000007402964,0.0001195176,0.00001727954,0.0005009433],"genre_scores_gemma":[0.9957762,0.0009478452,0.00128104,0.00002839193,0.000005447831,0.00001957828,0.0003089138,0.000007002221,0.001625529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005788049,"threshold_uncertainty_score":0.002264261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01193758885875333,"score_gpt":0.2461256921136966,"score_spread":0.2341881032549433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}