{"id":"W2744900448","doi":"10.1038/s41598-017-08315-0","title":"Ectodomain shedding of Limbic System-Associated Membrane Protein (LSAMP) by ADAM Metallopeptidases promotes neurite outgrowth in DRG neurons","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; McGill University","keywords":"Ectodomain; ADAM10; Neurite; Cell biology; Immunoglobulin superfamily; Biology; Metalloproteinase; Dorsal root ganglion; Cell adhesion; Population; Embryonic stem cell; Cell; Disintegrin; Cell adhesion molecule; Neuroscience; Matrix metalloproteinase; Receptor; In vitro; Genetics; Spinal cord; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00178713,0.0002420083,0.0003469962,0.0001086715,0.0003960622,0.0002880914,0.0005020741,0.0001496291,0.00001522258],"category_scores_gemma":[0.002417292,0.0002366793,0.0001791221,0.0001792573,0.0004047606,0.00002295909,0.000303867,0.0001216723,0.00000320519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003840866,"about_ca_system_score_gemma":0.0002330789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001364957,"about_ca_topic_score_gemma":0.00009747127,"domain_scores_codex":[0.9972163,0.0001859371,0.0006880481,0.001006766,0.0004774291,0.0004255226],"domain_scores_gemma":[0.997062,0.00002022256,0.0009011557,0.001687413,0.0001724781,0.0001567571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002374836,0.0002231362,0.01127931,0.0001311748,0.00003993668,0.0002134375,0.00003978339,0.00002808626,0.9870554,0.00001032451,0.0008983057,0.00005737894],"study_design_scores_gemma":[0.0003355468,0.0001017169,0.001930323,0.0002764311,0.00003547813,0.00004159664,0.0000343387,0.00007582617,0.9962153,0.0001258297,0.000586249,0.000241371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969408,0.0002741248,0.00003850494,0.000056475,0.001172077,0.0007657334,0.00004924113,0.00003986527,0.0006631645],"genre_scores_gemma":[0.9976922,0.000001811866,0.0001833922,0.000009326453,0.0000440136,0.00008638882,0.0002226306,0.00003927903,0.001720966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009348989,"threshold_uncertainty_score":0.9651501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01193758885875333,"score_gpt":0.2461256921136966,"score_spread":0.2341881032549433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}