{"id":"W2744940345","doi":"10.1136/gutjnl-2016-313598","title":"Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis","year":2017,"lang":"en","type":"article","venue":"Gut","topic":"Liver Diseases and Immunity","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; University Health Network; University of Calgary; Toronto General Hospital; University of Alberta","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Medical Research Council; National Institutes of Health; National Centre for the Replacement, Refinement and Reduction of Animals in Research; Novo Nordisk Fonden; Maag Lever Darm Stichting; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Institute for Health and Care Research; Sparks; Rosetrees Trust; Deutsche Forschungsgemeinschaft; PSC Partners Seeking a Cure","keywords":"Primary sclerosing cholangitis; Liver transplantation; Medicine; Allele; Liver disease; Single-nucleotide polymorphism; Cohort; Genome-wide association study; Internal medicine; Proportional hazards model; Transplantation; Disease; Genotype; Oncology; Biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005572644,0.0003588543,0.0002902118,0.0008016205,0.0003134918,0.0004758598,0.0002090971,0.0003468584,0.001996561],"category_scores_gemma":[0.002035384,0.0001357173,0.0005751717,0.001187372,0.0003335585,0.0001038439,0.0003027513,0.000349591,0.0001790773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001268099,"about_ca_system_score_gemma":0.0002040673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002097572,"about_ca_topic_score_gemma":0.002569361,"domain_scores_codex":[0.9994205,0.0001972988,0.00005734439,0.0001693734,0.00009879105,0.00005679345],"domain_scores_gemma":[0.9989926,0.0004240237,0.0003705754,0.00006236452,0.0000561061,0.00009429666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001045531,0.00004038395,0.9817294,0.0000333936,0.0004450864,0.0005605354,0.00008107415,0.0006097501,0.008861504,0.00009428008,0.0001983694,0.006300642],"study_design_scores_gemma":[0.00003673662,0.0001355722,0.9960874,0.000008213145,0.0001888998,0.0009226496,0.00004926947,0.001415671,0.000754286,0.0001643219,0.0002312708,0.00000567617],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990226,0.0002141837,0.0003251156,0.00004754931,0.000006107754,0.000003305616,0.0001984239,0.00001098647,0.0001717142],"genre_scores_gemma":[0.9995356,0.000055665,0.0001801052,0.000009526902,0.00000811131,0.000002645235,0.0001269327,0.000002788609,0.00007860534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002097572,"threshold_uncertainty_score":0.006679118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01778228700622699,"score_gpt":0.2774118886624687,"score_spread":0.2596296016562418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}