{"id":"W2745076116","doi":"10.1124/dmd.117.076927","title":"Involvement of Nuclear Factor κB, not Pregnane X Receptor, in Inflammation-Mediated Regulation of Hepatic Transporters","year":2017,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Pregnane X receptor; Multidrug resistance-associated protein 2; Nuclear receptor; Inflammation; Downregulation and upregulation; Chemistry; Transcription factor; Pharmacology; Endocrinology; Receptor; Internal medicine; Tumor necrosis factor alpha; Nitric oxide synthase; Transporter; Biology; Nitric oxide; ATP-binding cassette transporter; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005297763,0.0004071766,0.0005255788,0.0002879161,0.0003240108,0.001103673,0.0002442675,0.0003739642,0.002027763],"category_scores_gemma":[0.0005212066,0.000261599,0.0005499961,0.0001781775,0.0005994844,0.0007803824,0.0004816913,0.0006581744,0.0003753599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000551971,"about_ca_system_score_gemma":0.0006115172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009937008,"about_ca_topic_score_gemma":0.0009941397,"domain_scores_codex":[0.9994377,0.0001877623,0.00005233919,0.00007601595,0.00009297356,0.0001531731],"domain_scores_gemma":[0.9996729,0.00005331079,0.00011258,0.00003964268,0.00005328908,0.00006825047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00343958,0.0001622346,0.007425232,0.0004710351,0.0001426733,0.001331303,0.0004688628,0.0004580355,0.967301,0.003406001,0.0003027791,0.0150913],"study_design_scores_gemma":[0.0005109567,0.002177842,0.1483777,0.0002406699,0.0004142657,0.006590609,0.002123105,0.008714051,0.7998546,0.006219503,0.02462949,0.0001471914],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9473146,0.03852911,0.008295911,0.001495702,0.0001400088,0.00004148808,0.0003183417,0.00009997192,0.003764933],"genre_scores_gemma":[0.9914337,0.005056508,0.0008901916,0.0001010904,0.00003017781,0.00002043458,0.0001008506,0.00001891728,0.002348205],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002027763,"threshold_uncertainty_score":0.006783485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01001875389657366,"score_gpt":0.2274007511551549,"score_spread":0.2173819972585812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}