{"id":"W2745076116","doi":"10.1124/dmd.117.076927","title":"Involvement of Nuclear Factor κB, not Pregnane X Receptor, in Inflammation-Mediated Regulation of Hepatic Transporters","year":2017,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Pregnane X receptor; Multidrug resistance-associated protein 2; Nuclear receptor; Inflammation; Downregulation and upregulation; Chemistry; Transcription factor; Pharmacology; Endocrinology; Receptor; Internal medicine; Tumor necrosis factor alpha; Nitric oxide synthase; Transporter; Biology; Nitric oxide; ATP-binding cassette transporter; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001656681,0.0001214523,0.0003679778,0.0001440488,0.00007201573,0.00001136474,0.00006957641,0.00007472352,0.00007643009],"category_scores_gemma":[0.00001706775,0.0001047707,0.0000731028,0.00006945525,0.0001003294,0.0002601488,0.000007329581,0.00006959872,0.000001988452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001518019,"about_ca_system_score_gemma":0.00002614007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001968661,"about_ca_topic_score_gemma":0.0001162386,"domain_scores_codex":[0.998974,0.00002522526,0.0004398972,0.0001727228,0.0002671777,0.0001209601],"domain_scores_gemma":[0.9992605,0.00001583082,0.0003065672,0.0002674383,0.00007912781,0.00007052523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008937114,0.0002271641,0.02281178,0.0009115594,0.00005661387,0.00000495716,0.005832552,0.00001029592,0.9579662,0.003866252,0.00001246671,0.007406469],"study_design_scores_gemma":[0.002138023,0.00003834582,0.8484256,0.0005633463,0.0001267749,5.081831e-7,0.0002753073,0.0002640786,0.1476399,0.0002025281,0.0002264812,0.00009912604],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982822,0.0002237949,0.000144713,0.0004865796,0.0001458925,0.0004249092,0.00008026387,0.00001572506,0.0001959392],"genre_scores_gemma":[0.9985806,0.0004439612,0.0004998124,0.00002765163,0.00004132551,0.00001034952,0.0002999173,0.00001449273,0.00008187699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8256138,"threshold_uncertainty_score":0.4272424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01001875389657366,"score_gpt":0.2274007511551549,"score_spread":0.2173819972585812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}