{"id":"W2745136137","doi":"","title":"Abstract #5446: Mechanisms of myocyte cytotoxicity induced by the anticancer serine/threonine multikinase inhibitor sorafenib","year":2009,"lang":"en","type":"article","venue":"Cancer Research","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Sorafenib; Pharmacology; Cardiotoxicity; Kinase; Myocyte; Medicine; Apoptosis; Chemistry; Cancer research; Biochemistry; Internal medicine; Toxicity; Hepatocellular carcinoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002889674,0.0004399543,0.0005171825,0.000624846,0.0002537525,0.0004800487,0.0004618591,0.0005157536,0.01373709],"category_scores_gemma":[0.0002114343,0.0001937936,0.000397692,0.0002982845,0.0001616193,0.0003269881,0.0003395079,0.0004699079,0.004383292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004520415,"about_ca_system_score_gemma":0.0002328493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006744077,"about_ca_topic_score_gemma":0.0006364878,"domain_scores_codex":[0.9997572,0.00003965261,0.00001970808,0.00002576131,0.0001024497,0.00005520351],"domain_scores_gemma":[0.99985,0.00002415837,0.00002851317,0.0000159348,0.00005094261,0.00003049771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001693223,0.0003564707,0.001781997,0.0008831231,0.00006719795,0.001184597,0.00006937463,0.0005678938,0.9219037,0.001707731,0.008899015,0.06088574],"study_design_scores_gemma":[0.000365993,0.003139217,0.07538291,0.000151598,0.0001283878,0.004772181,0.0001007861,0.003275697,0.8381593,0.001266173,0.07322366,0.00003420576],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7903274,0.09936775,0.01594684,0.005549268,0.001701729,0.0006689575,0.00848698,0.001118737,0.07683235],"genre_scores_gemma":[0.9083003,0.02915445,0.002892697,0.0009580136,0.0004452416,0.0002504627,0.005725295,0.000122172,0.05215136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01373709,"threshold_uncertainty_score":0.04595512,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06600494864659141,"score_gpt":0.3899573391278255,"score_spread":0.3239523904812341,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}