{"id":"W2745149700","doi":"10.1200/jco.2013.31.15_suppl.5502","title":"Final results of OV16, a phase III randomized study of sequential cisplatin-topotecan and carboplatin-paclitaxel (CP) versus CP in first-line chemotherapy for advanced epithelial ovarian cancer (EOC): A GCIG study of NCIC CTG, EORTC-GCG, and GEICO.","year":2013,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Queen's University; Hôpital Notre-Dame; Vancouver Coastal Health; Baker Hughes (Canada); BC Cancer Agency","funders":"","keywords":"Medicine; Topotecan; Carboplatin; Internal medicine; Regimen; Hazard ratio; Clinical endpoint; Paclitaxel; Chemotherapy; Progression-free survival; Adverse effect; Cisplatin; Oncology; Randomized controlled trial; Surgery; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004571945,0.002049408,0.002854246,0.0004522902,0.0004293472,0.001144271,0.001307466,0.001970086,0.005792264],"category_scores_gemma":[0.002726773,0.000837165,0.001840999,0.000506762,0.000872136,0.0005859751,0.0004007703,0.003815842,0.001007654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001163245,"about_ca_system_score_gemma":0.002407448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001983388,"about_ca_topic_score_gemma":0.005077404,"domain_scores_codex":[0.999015,0.0006406485,0.00005206987,0.00009116655,0.00008602491,0.0001151353],"domain_scores_gemma":[0.9982981,0.000430756,0.0003176314,0.0001263527,0.0001353561,0.0006918461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.945336,0.01341433,0.002635238,0.0006238627,0.002024956,0.0001530322,0.0001006324,0.0009596272,0.008337131,0.0001553927,0.005533193,0.02072657],"study_design_scores_gemma":[0.9149678,0.07598325,0.004476933,0.00003310821,0.001032678,0.00006490944,0.00001556934,0.0002293631,0.0008808759,0.0001145696,0.00218533,0.00001557454],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9494604,0.006029177,0.001465452,0.002187354,0.0008208392,0.0184725,0.01527212,0.0001935852,0.006098563],"genre_scores_gemma":[0.9309463,0.004882898,0.00677934,0.003436662,0.0006687016,0.01536062,0.02303232,0.0001596191,0.01473347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005792264,"threshold_uncertainty_score":0.02417904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.123078166018521,"score_gpt":0.4772477868014978,"score_spread":0.3541696207829768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}