{"id":"W2745296515","doi":"10.1038/s41598-017-08665-9","title":"Enhancing Immune Responses to Cancer Vaccines Using Multi-Site Injections","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"OVC Pet Trust; Canadian Institutes of Health Research; Ministry of Agriculture, Food and Rural Affairs; Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Agriculture, Food and Rural Affairs","keywords":"Immune system; Antigen; Cancer vaccine; Immunology; Vaccination; CD8; Medicine; Antibody; Cytotoxic T cell; T cell; Immunotherapy; Tumor microenvironment; Virology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004571601,0.0007479634,0.0006096915,0.0005156514,0.0001155387,0.0004785691,0.0003828322,0.0007560246,0.001737583],"category_scores_gemma":[0.0002905645,0.000188056,0.0004816431,0.0002135303,0.0003041452,0.0005439086,0.0004852354,0.001279855,0.00046992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001981819,"about_ca_system_score_gemma":0.0001464342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001442043,"about_ca_topic_score_gemma":0.0003125896,"domain_scores_codex":[0.9995623,0.0001140788,0.00002922667,0.0001035636,0.00008788441,0.0001028789],"domain_scores_gemma":[0.9995682,0.0001338612,0.0001024161,0.0000898604,0.00003446162,0.00007136699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003128521,0.0005811396,0.0002824012,0.0001071649,0.00002058291,0.00005243788,0.00001773706,0.0005088237,0.9826012,0.0001994723,0.0001457524,0.01517029],"study_design_scores_gemma":[0.0001173231,0.00785026,0.001725641,0.000022584,0.00006528008,0.0002572223,0.00002211371,0.003474001,0.9831548,0.0001316417,0.003167879,0.00001128377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9548544,0.004343394,0.03703526,0.0002407978,0.0003132773,0.0003431326,0.0001354458,0.0004705375,0.002263761],"genre_scores_gemma":[0.9668864,0.001313424,0.02860906,0.0001222054,0.0001385101,0.0001510274,0.000131041,0.00006050584,0.002587774],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001737583,"threshold_uncertainty_score":0.005812824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03517531867101533,"score_gpt":0.3299161158447066,"score_spread":0.2947407971736913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}