{"id":"W2745331130","doi":"10.3390/molecules22081345","title":"Inhibitors of the Detoxifying Enzyme of the Phytoalexin Brassinin Based on Quinoline and Isoquinoline Scaffolds","year":2017,"lang":"en","type":"article","venue":"Molecules","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; University of Saskatchewan","keywords":"Phytoalexin; Isoquinoline; Quinoline; Enzyme; Chemistry; Leptosphaeria maculans; Detoxification (alternative medicine); Biochemistry; Pharmacology; Stereochemistry; Organic chemistry; Biology; Resveratrol; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001003768,0.0001485597,0.0001692005,0.00002042604,0.0001678053,0.0000192954,0.0005024117,0.0001131503,0.000002615279],"category_scores_gemma":[0.0001749646,0.00009565936,0.0001346002,0.00003356401,0.0005199409,0.000002970197,0.0003079051,0.00006591432,4.190913e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006363526,"about_ca_system_score_gemma":0.00005021586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001952379,"about_ca_topic_score_gemma":0.00002728602,"domain_scores_codex":[0.9991796,0.0000609132,0.0002194363,0.0002452075,0.0001364393,0.0001583832],"domain_scores_gemma":[0.9987107,0.00001563818,0.0003197029,0.00084753,0.00006994076,0.00003651682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005474733,0.00005459798,0.01237951,0.00003287446,0.00001915637,2.454898e-7,0.00002950384,0.00009307689,0.986114,0.00006610379,0.0002962477,0.0008599274],"study_design_scores_gemma":[0.0004702023,0.00008365154,0.07480823,0.00009931199,0.00001640173,0.000001048162,0.00002401284,0.0001409515,0.9235978,0.00009233636,0.0005666016,0.00009950788],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975401,0.0005674376,0.0001674014,0.0006268776,0.0001440541,0.0001591762,0.00005557671,0.000002894137,0.0007365199],"genre_scores_gemma":[0.9991363,0.00004395724,0.0002709739,0.0002915397,0.000123884,0.000006587138,0.000008658626,0.00001701743,0.0001010442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06251627,"threshold_uncertainty_score":0.3900875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01130195445650481,"score_gpt":0.2450831792068174,"score_spread":0.2337812247503126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}