{"id":"W2745331130","doi":"10.3390/molecules22081345","title":"Inhibitors of the Detoxifying Enzyme of the Phytoalexin Brassinin Based on Quinoline and Isoquinoline Scaffolds","year":2017,"lang":"en","type":"article","venue":"Molecules","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; University of Saskatchewan","keywords":"Phytoalexin; Isoquinoline; Quinoline; Enzyme; Chemistry; Leptosphaeria maculans; Detoxification (alternative medicine); Biochemistry; Pharmacology; Stereochemistry; Organic chemistry; Biology; Resveratrol; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001266022,0.0003696756,0.0002288193,0.0002434205,0.00009082361,0.0001414448,0.0003359145,0.0001806553,0.0008354628],"category_scores_gemma":[0.00007148899,0.0001130051,0.0002029962,0.0001331144,0.0001426801,0.0001557437,0.0001364063,0.0002387754,0.0002565151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001897109,"about_ca_system_score_gemma":0.0001246006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004762991,"about_ca_topic_score_gemma":0.001072401,"domain_scores_codex":[0.9999378,0.00001490536,0.000005375245,0.0000108733,0.00001481428,0.00001626917],"domain_scores_gemma":[0.9999564,0.000006443872,0.00001556648,0.000004742983,0.000008400139,0.000008442148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001597411,0.00005859447,0.0001565925,0.0001225294,0.0000111593,0.00008159277,0.00002134457,0.0004420465,0.9946404,0.0002694343,0.00007187605,0.003964755],"study_design_scores_gemma":[0.0001104396,0.001590098,0.002478558,0.00002498515,0.00003891433,0.0003964485,0.00002967043,0.001593971,0.9860563,0.00009103956,0.007574287,0.0000152271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821088,0.006895341,0.0064238,0.0001067432,0.00003327325,0.000127211,0.0003176102,0.000144941,0.00384233],"genre_scores_gemma":[0.9910206,0.003218582,0.003577305,0.000058742,0.000006772789,0.00005360428,0.0003854392,0.00001102567,0.001667992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008354628,"threshold_uncertainty_score":0.002794862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01130195445650481,"score_gpt":0.2450831792068174,"score_spread":0.2337812247503126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}