{"id":"W2745415858","doi":"10.1042/bcj20170469","title":"A novel image-based high-throughput screening assay discovers therapeutic candidates for adult polyglucosan body disease","year":2017,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Glycogen Storage Diseases and Myoclonus","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; Tel Aviv University; Wellcome Trust","keywords":"Glycogen; Glycogen storage disease; Glycogen synthase; Activator (genetics); Intracellular; Glycogen branching enzyme; Biology; Biochemistry; Molecular biology; Internal medicine; Chemistry; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001833111,0.0002815131,0.0003579412,0.00007256409,0.0006366177,0.0003551595,0.0003454097,0.0001061772,0.00009250465],"category_scores_gemma":[0.001006203,0.0002156938,0.0004732727,0.00004443074,0.0002367306,0.0002127061,0.00006631755,0.0003078671,0.000009613021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001032544,"about_ca_system_score_gemma":0.0004046422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001067667,"about_ca_topic_score_gemma":0.000002397148,"domain_scores_codex":[0.9983081,0.00002278745,0.000332751,0.000363318,0.000431728,0.0005412991],"domain_scores_gemma":[0.9976655,0.00009500518,0.0003103893,0.000568527,0.0003776297,0.0009828979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007077958,0.0008522889,0.01605269,0.0002072931,0.0005042773,0.001194508,0.00003989981,0.000004234614,0.9577806,0.0003031047,0.0109394,0.005043725],"study_design_scores_gemma":[0.07595541,0.002056017,0.2589568,0.003715603,0.007867153,0.002979255,0.0005714255,0.0143212,0.6196497,0.0015685,0.009289973,0.003068879],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8974335,0.00137979,0.0894255,0.009916319,0.0005466456,0.0005963797,0.0005638269,0.00005885992,0.00007918147],"genre_scores_gemma":[0.986729,0.00004664989,0.009692688,0.001961471,0.001139732,0.00003192318,0.0001887886,0.00005492293,0.0001548781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3381309,"threshold_uncertainty_score":0.8795736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01879972082779465,"score_gpt":0.3033185333187861,"score_spread":0.2845188124909915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}