{"id":"W2745415858","doi":"10.1042/bcj20170469","title":"A novel image-based high-throughput screening assay discovers therapeutic candidates for adult polyglucosan body disease","year":2017,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Glycogen Storage Diseases and Myoclonus","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Institute of Neurological Disorders and Stroke; Tel Aviv University; Wellcome Trust","keywords":"Glycogen; Glycogen storage disease; Glycogen synthase; Activator (genetics); Intracellular; Glycogen branching enzyme; Biology; Biochemistry; Molecular biology; Internal medicine; Chemistry; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004457397,0.001289155,0.001236191,0.001249776,0.0003468691,0.0007418314,0.0007323334,0.0008381735,0.003627592],"category_scores_gemma":[0.0003965971,0.0004177333,0.0007580724,0.0008331985,0.0002345418,0.0003765367,0.0005328544,0.0008864208,0.001203115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005565574,"about_ca_system_score_gemma":0.0005614635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001180628,"about_ca_topic_score_gemma":0.003218653,"domain_scores_codex":[0.9996518,0.0000582628,0.00001985758,0.00007280538,0.0001487617,0.00004848025],"domain_scores_gemma":[0.9998271,0.00004398141,0.00002696469,0.0000168908,0.00004968153,0.00003544861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004180447,0.0006729295,0.001549678,0.0003998192,0.0001031966,0.0003545695,0.00003955399,0.00397945,0.9633201,0.0003049041,0.002054008,0.02680374],"study_design_scores_gemma":[0.0003972487,0.006035949,0.005925933,0.00004527428,0.0004100683,0.001345334,0.00006818288,0.02358905,0.9474801,0.0003130668,0.01428026,0.0001094627],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8898416,0.009477518,0.06056227,0.001490731,0.0002388372,0.001846707,0.01267345,0.003274128,0.02059473],"genre_scores_gemma":[0.9014935,0.008034389,0.05652316,0.0008334131,0.00005588218,0.0009493907,0.01443942,0.0001724475,0.01749838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003627592,"threshold_uncertainty_score":0.01213551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01879972082779465,"score_gpt":0.3033185333187861,"score_spread":0.2845188124909915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}