{"id":"W2745485917","doi":"10.1016/j.bbapap.2017.08.018","title":"Anthranilate phosphoribosyltransferase: Binding determinants for 5′-phospho-alpha- d -ribosyl-1′-pyrophosphate (PRPP) and the implications for inhibitor design","year":2017,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Health Research Council of New Zealand; Foundation for Research, Science and Technology; BCFRST Foundation","keywords":"Chemistry; Moiety; Phosphonate; Stereochemistry; Binding site; Pyrophosphate; Biochemistry; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002648131,0.0004637568,0.0003189496,0.000142004,0.0002390032,0.0003857546,0.0003803669,0.000374129,0.001642961],"category_scores_gemma":[0.0004705554,0.0002388783,0.0002155939,0.000124176,0.0002967191,0.0003779629,0.0001617489,0.0007017008,0.0007704125],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005628751,"about_ca_system_score_gemma":0.0002270585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001165136,"about_ca_topic_score_gemma":0.001001281,"domain_scores_codex":[0.9998821,0.00002946116,0.00000666278,0.00002947347,0.00003020754,0.00002212026],"domain_scores_gemma":[0.9997788,0.00008532099,0.00004155553,0.00001296007,0.00002389282,0.0000575044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002288867,0.00004423988,0.0001995561,0.0000378237,0.000004009672,0.00009622213,0.00001988889,0.0006431807,0.9947901,0.0006466875,0.0001145502,0.003174986],"study_design_scores_gemma":[0.00002052255,0.0001426462,0.001169022,0.000005212702,0.00001068178,0.0003599109,0.0000174262,0.005765405,0.9897242,0.0003150878,0.002461121,0.000008724247],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9674646,0.003364951,0.02338692,0.0005222181,0.00004996587,0.00005304059,0.0001697556,0.0003231621,0.004665523],"genre_scores_gemma":[0.9895384,0.0008302854,0.007028846,0.00007332685,0.0000233214,0.00001470203,0.0003265413,0.00005588087,0.002108591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001642961,"threshold_uncertainty_score":0.005496264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0299267413824414,"score_gpt":0.3120433310634619,"score_spread":0.2821165896810205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}