{"id":"W2745485917","doi":"10.1016/j.bbapap.2017.08.018","title":"Anthranilate phosphoribosyltransferase: Binding determinants for 5′-phospho-alpha- d -ribosyl-1′-pyrophosphate (PRPP) and the implications for inhibitor design","year":2017,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Health Research Council of New Zealand; Foundation for Research, Science and Technology; BCFRST Foundation","keywords":"Chemistry; Moiety; Phosphonate; Stereochemistry; Binding site; Pyrophosphate; Biochemistry; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.0007584268,0.000463925,0.000459342,0.0000463445,0.001545552,0.0004983094,0.0006913719,0.0003588692,0.000001808594],"category_scores_gemma":[0.0003322837,0.0003456304,0.0002634819,0.00007675164,0.0009634646,0.00003482314,0.0003736812,0.000233978,0.000001455282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001992899,"about_ca_system_score_gemma":0.0001774961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006116892,"about_ca_topic_score_gemma":0.00001028576,"domain_scores_codex":[0.9977074,0.00009749246,0.0004260114,0.0009442426,0.0001586074,0.0006662198],"domain_scores_gemma":[0.998189,0.00009519622,0.0003023739,0.0009628398,0.0002139989,0.0002365312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002524734,0.0001020336,0.0000227474,0.0001563359,0.0001270302,6.068015e-7,0.00007543938,4.928341e-7,0.9916466,0.0005794493,0.0002503218,0.004514235],"study_design_scores_gemma":[0.004278692,0.0008502394,0.0006010039,0.00007984498,0.0001023025,0.00001435693,0.00001590036,0.0002633779,0.9898972,0.001919762,0.00147007,0.0005072383],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9695269,0.000674192,0.0160096,0.006069493,0.0001112353,0.00692647,0.0006305546,0.0000263452,0.00002514159],"genre_scores_gemma":[0.9793498,0.002059676,0.01451997,0.0002971439,0.0002965935,0.003015443,0.0001641283,0.00009624409,0.0002010217],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009822802,"threshold_uncertainty_score":0.9998996,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0299267413824414,"score_gpt":0.3120433310634619,"score_spread":0.2821165896810205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}