{"id":"W2745580489","doi":"10.1074/jbc.m117.787853","title":"Bacterial PhyA protein-tyrosine phosphatase-like myo-inositol phosphatases in complex with the Ins(1,3,4,5)P4 and Ins(1,4,5)P3 second messengers","year":2017,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agriculture and Agri-Food Canada; University of Lethbridge","funders":"","keywords":"Second messenger system; Phosphatase; Inositol; Protein tyrosine phosphatase; Chemistry; Tyrosine; Cell biology; Biochemistry; Biology; Phosphorylation; Signal transduction; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002270232,0.0002141028,0.0003149378,0.000236901,0.0001933453,0.0004300255,0.0002659043,0.0003101427,0.001411095],"category_scores_gemma":[0.0004128154,0.0001757349,0.0001481486,0.0003774243,0.00033737,0.0001665506,0.0002173388,0.0006640105,0.0003254318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005316046,"about_ca_system_score_gemma":0.0003243533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001974889,"about_ca_topic_score_gemma":0.002813298,"domain_scores_codex":[0.9997125,0.00004326792,0.00001743926,0.00003577519,0.0001124924,0.00007846316],"domain_scores_gemma":[0.9998026,0.00004472592,0.00002914868,0.0000140145,0.00002145574,0.00008797556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006074067,0.0000639582,0.000596794,0.00004074832,0.00001761749,0.0001513435,0.00003223482,0.0001120264,0.997439,0.0001972206,0.0001387281,0.0006029504],"study_design_scores_gemma":[0.0001580956,0.0003956004,0.0512358,0.00001716335,0.00004245349,0.0009603167,0.0002537656,0.008301735,0.9353332,0.0003597218,0.002919011,0.00002308779],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981087,0.0004083262,0.000307659,0.0001632197,0.00003910871,0.000008334272,0.0002251582,0.0000138459,0.000725559],"genre_scores_gemma":[0.9959716,0.0002484481,0.0005980241,0.0000700736,0.000012612,0.0000122625,0.0008515466,0.000007415954,0.002227911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001974889,"threshold_uncertainty_score":0.004720509,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01918784008268297,"score_gpt":0.2514194975709658,"score_spread":0.2322316574882828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}