{"id":"W2745668487","doi":"10.1016/s1470-2045(17)30576-4","title":"Guadecitabine (SGI-110) in treatment-naive patients with acute myeloid leukaemia: phase 2 results from a multicentre, randomised, phase 1/2 trial","year":2017,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":154,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Cancer Institute; Astex Pharmaceuticals","keywords":"Medicine; Myeloid leukaemia; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001311945,0.001347231,0.002513549,0.0002698913,0.0002491306,0.0008505037,0.0006429217,0.001272337,0.003607216],"category_scores_gemma":[0.0013319,0.0004938839,0.001265599,0.0004151551,0.0009347418,0.0008644303,0.0003857636,0.002844907,0.0008058237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000902816,"about_ca_system_score_gemma":0.0009461579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001175222,"about_ca_topic_score_gemma":0.003626398,"domain_scores_codex":[0.9995203,0.0002672865,0.00002326059,0.00007131704,0.00003362943,0.00008428867],"domain_scores_gemma":[0.9995184,0.0001230422,0.0001045438,0.00003681583,0.00002733823,0.0001899957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9353051,0.003617659,0.00137829,0.001346789,0.001579586,0.00009400496,0.0001179829,0.0007460276,0.007218473,0.0002086423,0.003211299,0.0451763],"study_design_scores_gemma":[0.9509523,0.04302039,0.003060764,0.00004469929,0.0004656301,0.00009335431,0.00003097127,0.000276281,0.0004554389,0.0002116666,0.001370737,0.00001776937],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852161,0.008417782,0.0004224899,0.001100646,0.0004327313,0.001284522,0.001173316,0.0001309539,0.001821435],"genre_scores_gemma":[0.9835981,0.006058892,0.001519772,0.001851778,0.0002195278,0.001575028,0.002259975,0.00004056985,0.002876381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003607216,"threshold_uncertainty_score":0.01206732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05811141162999822,"score_gpt":0.3966105076241037,"score_spread":0.3384990959941055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}