{"id":"W2745719851","doi":"10.1016/j.celrep.2017.07.052","title":"An Integrated Systems Biology Approach Identifies TRIM25 as a Key Determinant of Breast Cancer Metastasis","year":2017,"lang":"en","type":"article","venue":"Cell Reports","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":128,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health; Memorial Sloan-Kettering Cancer Center; National Institute of Diabetes and Digestive and Kidney Diseases; U.S. Department of Defense; Starr Cancer Consortium","keywords":"Metastasis; Interactome; Biology; Regulator; Breast cancer; Transcriptional regulation; Transcription factor; Cancer; Regulation of gene expression; Computational biology; Metastatic breast cancer; Cancer research; Bioinformatics; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005312756,0.0002305221,0.0005882561,0.0001523199,0.0003066282,0.00006949426,0.0003941653,0.0002910642,0.0003528942],"category_scores_gemma":[0.0001201351,0.0001703753,0.0001543635,0.00004805229,0.0004995307,0.0001693852,0.0001162248,0.0002145767,0.00004725426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003813855,"about_ca_system_score_gemma":0.0002192368,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006774955,"about_ca_topic_score_gemma":0.00004050922,"domain_scores_codex":[0.9981932,0.0003460408,0.0006495899,0.0004317205,0.0000358245,0.0003436247],"domain_scores_gemma":[0.9976306,0.00004347208,0.0009010175,0.001164072,0.0002277611,0.00003308795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004880397,0.0002748464,0.0044686,0.00009091487,0.0002421062,0.0001056191,0.000403361,0.000004433456,0.9875578,0.00008931475,0.0009173955,0.005357562],"study_design_scores_gemma":[0.0006219522,0.0003141253,0.01293603,0.000114074,0.0001806117,0.003643812,0.001155215,0.00001844556,0.9566754,0.00003152837,0.02400661,0.0003022584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869599,0.005730354,0.0001913875,0.00002534489,0.002465487,0.0002987116,0.00009532055,0.00004605662,0.004187491],"genre_scores_gemma":[0.9881471,0.0002047793,0.0000284726,0.00001343687,0.00002469868,0.00006268471,0.0001078513,0.00002167939,0.01138934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03088246,"threshold_uncertainty_score":0.999839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0193842585392479,"score_gpt":0.2923952288889807,"score_spread":0.2730109703497328,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}