{"id":"W2746084941","doi":"10.1016/s1473-3099(17)30496-6","title":"Glecaprevir plus pibrentasvir for chronic hepatitis C virus genotype 1, 2, 4, 5, or 6 infection in adults with compensated cirrhosis (EXPEDITION-1): a single-arm, open-label, multicentre phase 3 trial","year":2017,"lang":"en","type":"article","venue":"The Lancet Infectious Diseases","topic":"Hepatitis C virus research","field":"Medicine","cited_by":343,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Gilead Sciences","keywords":"Ribavirin; Medicine; Internal medicine; Regimen; Sofosbuvir; Cirrhosis; Hepatitis C virus; Gastroenterology; Hepatitis C; Pegylated interferon; Population; Clinical endpoint; Tolerability; Clinical trial; Adverse effect; Immunology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001869472,0.002169628,0.002840466,0.0004255585,0.0003846679,0.001080747,0.0009832152,0.001367655,0.004588453],"category_scores_gemma":[0.00124604,0.0005445742,0.002286229,0.0004281995,0.001114921,0.001497828,0.0004144441,0.003697156,0.001071039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000919856,"about_ca_system_score_gemma":0.001329235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001770618,"about_ca_topic_score_gemma":0.005018492,"domain_scores_codex":[0.9994307,0.0002753806,0.00002331649,0.00009091885,0.00004303009,0.0001365765],"domain_scores_gemma":[0.9993315,0.0001550832,0.000138417,0.00006868473,0.00004057396,0.0002656887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9482287,0.007058739,0.001257946,0.000778823,0.001387372,0.00008035784,0.0001171204,0.0009680928,0.003569613,0.0002363146,0.001962089,0.03435474],"study_design_scores_gemma":[0.9301941,0.06496737,0.002505779,0.00003466446,0.0003911851,0.00007220293,0.00004323527,0.0005918427,0.000333608,0.0001985487,0.0006437387,0.00002351598],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906195,0.004254691,0.0004245676,0.0005201832,0.0002883968,0.001278682,0.0008330856,0.0001640522,0.001616835],"genre_scores_gemma":[0.9869746,0.003021277,0.001866377,0.001136622,0.0002299086,0.001658054,0.001700322,0.00004335443,0.003369598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004588453,"threshold_uncertainty_score":0.01534992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1002147116584242,"score_gpt":0.3977524272771292,"score_spread":0.297537715618705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}