{"id":"W2746084941","doi":"10.1016/s1473-3099(17)30496-6","title":"Glecaprevir plus pibrentasvir for chronic hepatitis C virus genotype 1, 2, 4, 5, or 6 infection in adults with compensated cirrhosis (EXPEDITION-1): a single-arm, open-label, multicentre phase 3 trial","year":2017,"lang":"en","type":"article","venue":"The Lancet Infectious Diseases","topic":"Hepatitis C virus research","field":"Medicine","cited_by":343,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Gilead Sciences","keywords":"Ribavirin; Medicine; Internal medicine; Regimen; Sofosbuvir; Cirrhosis; Hepatitis C virus; Gastroenterology; Hepatitis C; Pegylated interferon; Population; Clinical endpoint; Tolerability; Clinical trial; Adverse effect; Immunology; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003224714,0.0003852845,0.0009329077,0.000189106,0.0009564749,0.0005173762,0.0005485578,0.0001370651,0.0005147668],"category_scores_gemma":[0.001451534,0.0002614977,0.0001044062,0.0003141551,0.000334473,0.0006348165,0.0002514473,0.0003884557,0.00008852164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001047628,"about_ca_system_score_gemma":0.0008489477,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.02277881,"about_ca_topic_score_gemma":0.09697995,"domain_scores_codex":[0.997334,0.0002963989,0.0005085415,0.0006057431,0.0004825025,0.000772815],"domain_scores_gemma":[0.9972829,0.0004622044,0.0004088577,0.001206411,0.0003330052,0.0003066177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.470262,0.02600188,0.3540012,0.002262968,0.001193802,0.0004382313,0.001220345,0.0001498878,0.002297439,0.0002001073,0.01350463,0.1284676],"study_design_scores_gemma":[0.8007526,0.03748337,0.1279746,0.002897588,0.0009526428,0.00007075704,0.00003267474,0.01153971,0.001592961,0.0002651791,0.01542879,0.001009114],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987528,0.0004212187,0.0001703636,0.000664617,0.0005053105,0.008162487,0.0008797084,0.0002520412,0.001416295],"genre_scores_gemma":[0.9913648,0.003272869,0.00008391381,0.0004690217,0.001726821,0.002304131,0.0005373357,0.00008821175,0.0001528963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3304906,"threshold_uncertainty_score":0.9999837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1002147116584242,"score_gpt":0.3977524272771292,"score_spread":0.297537715618705,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}