{"id":"W2746087605","doi":"10.1155/2017/5015307","title":"Chaperone-Based Therapies for Disease Modification in Parkinson’s Disease","year":2017,"lang":"en","type":"review","venue":"Parkinson s Disease","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of Toronto; University of British Columbia; Canada Research Chairs; University Health Network","funders":"Allergan; Canadian Institutes of Health Research; Parkinson Canada; University of Toronto; J.P. Bickell Foundation; Natural Sciences and Engineering Research Council of Canada; Parkinson's UK; Michael J. Fox Foundation for Parkinson's Research","keywords":"Proteostasis; Medicine; Disease; Parkinson's disease; Chaperone (clinical); Neuroprotection; Chemical chaperone; Bioinformatics; Protein folding; Neuroscience; Synucleinopathies; Alpha-synuclein; Unfolded protein response; Pharmacology; Biology; Cell biology; Pathology; Endoplasmic reticulum","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003640359,0.0007166393,0.001109744,0.001872732,0.0002518316,0.0006743901,0.0006831005,0.0009536003,0.004547316],"category_scores_gemma":[0.000329222,0.0001957753,0.00051659,0.001240818,0.0003004101,0.0008145117,0.000601696,0.001712689,0.002606055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004062856,"about_ca_system_score_gemma":0.0005254318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005150764,"about_ca_topic_score_gemma":0.001146117,"domain_scores_codex":[0.9998811,0.00001834927,0.00001651894,0.00001778547,0.00005142731,0.00001481638],"domain_scores_gemma":[0.999886,0.00004490193,0.00001793541,0.000004405262,0.00003193782,0.00001484441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001006847,0.0001446687,0.0000874571,0.01556932,0.00009181794,0.0002904688,0.00006764931,0.0002949212,0.005798812,0.003579913,0.02216694,0.9518074],"study_design_scores_gemma":[0.00003309291,0.0001764221,0.0005185595,0.002252489,0.0001024146,0.001134347,0.00004039172,0.00007681429,0.001224281,0.001616005,0.9928099,0.00001547163],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002831167,0.9976737,0.0001988936,0.0001695896,0.0001929866,0.00001209422,0.00002895172,0.00001579416,0.001424771],"genre_scores_gemma":[0.001297435,0.997139,0.000290775,0.0001400086,0.0001009613,0.00001384965,0.00005324934,0.000002733519,0.0009619566],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004547316,"threshold_uncertainty_score":0.0152123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1209270583638844,"score_gpt":0.4058430058987924,"score_spread":0.284915947534908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}