{"id":"W2746087605","doi":"10.1155/2017/5015307","title":"Chaperone-Based Therapies for Disease Modification in Parkinson’s Disease","year":2017,"lang":"en","type":"review","venue":"Parkinson s Disease","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of Toronto; University of British Columbia; Canada Research Chairs; University Health Network","funders":"Allergan; Canadian Institutes of Health Research; Parkinson Canada; University of Toronto; J.P. Bickell Foundation; Natural Sciences and Engineering Research Council of Canada; Parkinson's UK; Michael J. Fox Foundation for Parkinson's Research","keywords":"Proteostasis; Medicine; Disease; Parkinson's disease; Chaperone (clinical); Neuroprotection; Chemical chaperone; Bioinformatics; Protein folding; Neuroscience; Synucleinopathies; Alpha-synuclein; Unfolded protein response; Pharmacology; Biology; Cell biology; Pathology; Endoplasmic reticulum","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007020114,0.0008819279,0.001152679,0.0003841096,0.0003814444,0.0002575264,0.001373731,0.0003703303,0.00006184385],"category_scores_gemma":[0.001285097,0.0008114593,0.00111829,0.0001809378,0.0002859251,0.00002121528,0.0002594618,0.0003408475,0.0000882269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002185179,"about_ca_system_score_gemma":0.003410057,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002674923,"about_ca_topic_score_gemma":0.00002552733,"domain_scores_codex":[0.995219,0.0005884228,0.0008166734,0.00179261,0.0005952209,0.0009880705],"domain_scores_gemma":[0.9946517,0.0001026014,0.0004336606,0.002822172,0.0001874494,0.001802391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002196764,0.0009838417,0.001983164,0.02183551,0.000191714,0.0001248236,0.00001636819,0.000040177,0.00004287608,0.00008134209,0.001636373,0.970867],"study_design_scores_gemma":[0.001005462,0.00007716708,0.00300136,0.002690804,0.0004006383,4.353425e-7,0.000003706372,0.0006135234,0.00001625821,0.000106038,0.9911885,0.0008961157],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0007688968,0.9893716,0.0008938489,0.0004207584,0.0001953139,0.005444831,0.00278315,0.00004979709,0.00007183395],"genre_scores_gemma":[0.04052209,0.9401057,0.0001718216,0.0001536096,0.0007088154,0.01128315,0.005911656,0.0002374292,0.0009056838],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9895521,"threshold_uncertainty_score":0.9994336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1209270583638844,"score_gpt":0.4058430058987924,"score_spread":0.284915947534908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}