{"id":"W2746101152","doi":"10.1016/s0140-6736(17)31816-0","title":"KEYNOTE-006: a success in melanoma, but a long way to go","year":2017,"lang":"en","type":"letter","venue":"The Lancet","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences North","funders":"","keywords":"Ipilimumab; Medicine; Nivolumab; Melanoma; Dacarbazine; Internal medicine; Oncology; Discontinuation; Adverse effect; Trametinib; Cancer; Immunotherapy; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00359939,0.001114608,0.00174643,0.0005571831,0.003413038,0.006024361,0.001924896,0.05520241,0.01922332],"category_scores_gemma":[0.01874745,0.0005294671,0.001452232,0.0005320505,0.004240763,0.005819971,0.002445337,0.0525535,0.01734698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005058608,"about_ca_system_score_gemma":0.003665187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003352905,"about_ca_topic_score_gemma":0.005763218,"domain_scores_codex":[0.99607,0.001283205,0.0002607376,0.0005015798,0.001267471,0.0006169901],"domain_scores_gemma":[0.9923396,0.004062855,0.0004599835,0.0002142899,0.001208496,0.001714822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007799078,0.00001975136,0.00009902644,0.0000734095,0.00001097086,0.000439608,0.00003307532,0.00002789038,0.0001182743,0.002739382,0.987963,0.008397592],"study_design_scores_gemma":[0.0001978245,0.00009845165,0.0002696591,0.0003810499,0.0000216263,0.0005144662,0.0002385787,0.0001372132,0.0001709107,0.01382597,0.9841037,0.00004058374],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"editorial","genre_scores_codex":[0.0001057606,0.004754628,0.0000559317,0.96244,0.02963707,0.000006411057,0.00004484447,0.00001875351,0.002936671],"genre_scores_gemma":[0.00208835,0.003112799,0.0001240664,0.9157966,0.06659348,0.00002399139,0.00003374969,0.00003262086,0.01219426],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.05520241,"threshold_uncertainty_score":0.06430835,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06118385273849644,"score_gpt":0.3521789488700232,"score_spread":0.2909950961315267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}