{"id":"W2746319289","doi":"10.1161/circresaha.117.311541","title":"Allele-Specific Gene Silencing","year":2017,"lang":"en","type":"letter","venue":"Circulation Research","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Montreal Heart Institute","funders":"Canadian Institutes of Health Research","keywords":"Gene silencing; Allele; Gene; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007662225,0.0002133424,0.0005036127,0.0004532495,0.0006396155,0.00009687769,0.0002259204,0.001054126,0.0006251813],"category_scores_gemma":[0.0002512363,0.0002039797,0.0002881945,0.000172057,0.0003121104,0.00008059908,0.0001016497,0.004420002,0.001212693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003453851,"about_ca_system_score_gemma":0.0003900599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004627409,"about_ca_topic_score_gemma":0.000001068303,"domain_scores_codex":[0.9970105,0.0003184651,0.0002607006,0.000658033,0.001014037,0.0007382666],"domain_scores_gemma":[0.997609,0.0002678548,0.0001105625,0.001328016,0.0005858269,0.00009869235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000444647,0.00001260485,0.0001697354,0.0001354068,0.0001089767,0.004823452,0.0000697721,0.00006881663,0.01501361,0.00002964351,0.9770551,0.002468428],"study_design_scores_gemma":[0.0008146326,0.0001497838,0.03054051,0.0001998596,0.00005470792,0.001046648,0.00001145454,0.0003505212,0.001040474,0.001066011,0.9643719,0.0003535342],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.2180875,0.004074516,0.0001547722,0.7450536,0.0008444005,0.00151072,0.00002953971,0.0001629489,0.03008202],"genre_scores_gemma":[0.8206875,0.0009563389,0.0001444413,0.1127691,0.04193956,0.000182969,0.002931863,0.0001779712,0.02021024],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.6322845,"threshold_uncertainty_score":0.999565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1285000888563548,"score_gpt":0.3868771191401459,"score_spread":0.2583770302837911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}