{"id":"W2746496013","doi":"10.1080/21541264.2017.1331156","title":"Topological requirements of the mitochondrial heavy-strand promoters","year":2017,"lang":"en","type":"article","venue":"Transcription","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Promoter; DNA supercoil; Mitochondrial DNA; TFAM; Transcription (linguistics); Heavy strand; Biology; Genetics; Plasmid; Gene; Computational biology; Cell biology; Gene expression; RNA; Transfer RNA; DNA replication","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00042058,0.0002338572,0.0002577289,0.0002653469,0.0001965783,0.0005763933,0.0002787202,0.0002296087,0.0008943024],"category_scores_gemma":[0.001174298,0.0002278881,0.000157231,0.0001600379,0.0004214843,0.0004796526,0.0003886586,0.0003877577,0.000388682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003401277,"about_ca_system_score_gemma":0.0002647359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001796199,"about_ca_topic_score_gemma":0.0004385934,"domain_scores_codex":[0.999569,0.0001190942,0.00003808544,0.00006873114,0.0001438454,0.00006123881],"domain_scores_gemma":[0.9987361,0.0005403283,0.0002561508,0.00008833723,0.000169362,0.0002097192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005887336,0.000005381946,0.0002946985,0.00002826564,0.000001224179,0.00001797512,0.00001937795,0.0001148306,0.9988554,0.0001859954,0.000005241754,0.000412815],"study_design_scores_gemma":[0.000007783055,0.0001226951,0.003839513,0.000005288165,0.000006113787,0.0002002785,0.00006167701,0.001367392,0.9933841,0.0002484899,0.0007484284,0.00000815049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898682,0.0003825425,0.008710918,0.00005580249,0.000007081412,0.00001659021,0.0001386917,0.00005987031,0.0007602922],"genre_scores_gemma":[0.9950152,0.0001808215,0.003909882,0.00001508384,0.00000558177,0.00002386977,0.0004863082,0.00003079369,0.0003324967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008943024,"threshold_uncertainty_score":0.002991736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03695520903223515,"score_gpt":0.2861674300910647,"score_spread":0.2492122210588295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}