{"id":"W2746496013","doi":"10.1080/21541264.2017.1331156","title":"Topological requirements of the mitochondrial heavy-strand promoters","year":2017,"lang":"en","type":"article","venue":"Transcription","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Promoter; DNA supercoil; Mitochondrial DNA; TFAM; Transcription (linguistics); Heavy strand; Biology; Genetics; Plasmid; Gene; Computational biology; Cell biology; Gene expression; RNA; Transfer RNA; DNA replication","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008065809,0.00008121887,0.00009386289,0.00001072396,0.0001985465,0.00001860023,0.0002507406,0.00013926,0.0000753891],"category_scores_gemma":[0.00005913811,0.00005660536,0.000119751,0.00001422393,0.0001925773,0.000005340779,0.00002518458,0.0000664696,0.000005428824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004654422,"about_ca_system_score_gemma":0.00002127819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001968804,"about_ca_topic_score_gemma":0.00006258945,"domain_scores_codex":[0.9993688,0.00006865309,0.0001542002,0.0001921532,0.00009716648,0.000119067],"domain_scores_gemma":[0.9993694,0.000001929187,0.00009543182,0.0004659965,0.0000351645,0.00003210008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003532124,0.00003927051,0.001527676,0.000008475759,0.00001341779,4.851148e-7,0.00005866425,0.000002893871,0.9965258,0.0002412607,0.0004555912,0.0007732838],"study_design_scores_gemma":[0.001720564,0.000475855,0.02459598,0.00001763866,0.00003561653,0.00001437693,0.00003204274,0.000007537248,0.9513021,0.0006253569,0.02104649,0.0001264566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901491,0.00004787598,0.003755779,0.0007586666,0.002607197,0.0002667736,0.00001558796,0.000006464837,0.002392506],"genre_scores_gemma":[0.9980753,0.00002932127,0.0004205138,0.000132595,0.0003429521,0.00001079076,0.00001751608,0.000006308727,0.0009646696],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04522368,"threshold_uncertainty_score":0.23083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03695520903223515,"score_gpt":0.2861674300910647,"score_spread":0.2492122210588295,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}