{"id":"W2746510926","doi":"10.1021/acs.jmedchem.7b00463","title":"Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against <i>Trypanosoma cruzi</i>","year":2017,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Wellcome Trust; Wellcome","keywords":"Benznidazole; Nifurtimox; Trypanosoma cruzi; Chagas disease; Pharmacology; Vero cell; Trypanocidal agent; Chemistry; African trypanosomiasis; Biology; In vitro; Parasite hosting; Virology; Trypanosomiasis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005208539,0.0001499233,0.0004762972,0.00006940849,0.0001708822,0.00007081335,0.0002864485,0.0001192173,0.00005576252],"category_scores_gemma":[0.001634157,0.0001154035,0.0001265637,0.00007252635,0.0005538524,0.0005340479,0.00009720638,0.0004119524,7.291554e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000667581,"about_ca_system_score_gemma":0.0003638945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007753484,"about_ca_topic_score_gemma":8.726607e-7,"domain_scores_codex":[0.9983652,0.00001818197,0.0005955609,0.0001489542,0.0006524702,0.0002196123],"domain_scores_gemma":[0.9978796,0.0000856541,0.0007997893,0.0004828125,0.0004528855,0.0002992299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000618879,0.0001285005,0.003172401,0.0004111102,0.000128898,0.0001353829,0.00008818141,0.00005666821,0.9912125,0.00002665035,0.001492846,0.002527979],"study_design_scores_gemma":[0.006334012,0.000881905,0.3039128,0.001692912,0.0003597698,0.003804842,0.001421797,0.0004081556,0.6759685,0.0001670711,0.004782652,0.0002656784],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819952,0.001667971,0.001066334,0.005270514,0.0001345274,0.0001251835,0.0000246896,0.000008689691,0.009706946],"genre_scores_gemma":[0.9933225,0.002634039,0.001887504,0.0001114843,0.0007386125,0.000001927283,0.00001123273,0.00001738016,0.001275324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.315244,"threshold_uncertainty_score":0.4706016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01890018372372524,"score_gpt":0.2964081254782869,"score_spread":0.2775079417545617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}