{"id":"W2746510926","doi":"10.1021/acs.jmedchem.7b00463","title":"Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against <i>Trypanosoma cruzi</i>","year":2017,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Wellcome Trust; Wellcome","keywords":"Benznidazole; Nifurtimox; Trypanosoma cruzi; Chagas disease; Pharmacology; Vero cell; Trypanocidal agent; Chemistry; African trypanosomiasis; Biology; In vitro; Parasite hosting; Virology; Trypanosomiasis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001415554,0.0004045152,0.000253663,0.0003265562,0.0001221526,0.0002019942,0.0003133591,0.0001971108,0.001138707],"category_scores_gemma":[0.000134853,0.0001132862,0.0002077973,0.0002873013,0.0001201269,0.0002302923,0.0001659769,0.000309484,0.0003212405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002002046,"about_ca_system_score_gemma":0.0002207189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005907307,"about_ca_topic_score_gemma":0.002160858,"domain_scores_codex":[0.9999222,0.00001540035,0.000007650178,0.00001401872,0.00002036477,0.00002039437],"domain_scores_gemma":[0.9999574,0.000004807518,0.00001089863,0.000003575569,0.00001187877,0.00001141849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002572864,0.0003419396,0.0004156986,0.0002336071,0.00002527161,0.0004499317,0.00005826892,0.001711995,0.974362,0.0006129879,0.0004312985,0.02109966],"study_design_scores_gemma":[0.0003003576,0.01060973,0.005121537,0.00006268118,0.0001185635,0.001306876,0.00008348603,0.003529117,0.9613714,0.0002858365,0.0171745,0.00003580165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9749553,0.006536572,0.007423557,0.0002671906,0.00006131912,0.0003730377,0.0007538074,0.0001902674,0.009438902],"genre_scores_gemma":[0.9834614,0.005328126,0.00754107,0.0001528768,0.00002153372,0.00007836126,0.00091115,0.00002171962,0.002483739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001138707,"threshold_uncertainty_score":0.003809392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01890018372372524,"score_gpt":0.2964081254782869,"score_spread":0.2775079417545617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}