{"id":"W2746632276","doi":"10.1158/0008-5472.can-17-0925","title":"Human Pluripotent Stem Cell–Derived <i>TSC2</i> -Haploinsufficient Smooth Muscle Cells Recapitulate Features of Lymphangioleiomyomatosis","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Tuberous Sclerosis Complex Research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Esri (Canada); University of Ottawa","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Tehran University of Medical Sciences and Health Services; McGill University Health Centre; University of Ottawa","keywords":"Lymphangioleiomyomatosis; TSC2; Induced pluripotent stem cell; Biology; TSC1; Cancer research; Reprogramming; Haploinsufficiency; Stem cell; Germline mutation; Cell biology; Tuberous sclerosis; Mutation; Cell; Pathology; Genetics; PI3K/AKT/mTOR pathway; Signal transduction; Embryonic stem cell; Phenotype; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts"],"consensus_categories":[],"category_scores_codex":[0.001832294,0.0003409774,0.0007383933,0.0005948769,0.001426731,0.0002715439,0.001447323,0.0002232569,0.0005540111],"category_scores_gemma":[0.0000730029,0.0002986895,0.0003193406,0.0004531026,0.001245897,0.0001706722,0.001071552,0.0007726046,0.0001369523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000686157,"about_ca_system_score_gemma":0.0006754948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004032996,"about_ca_topic_score_gemma":0.0002538767,"domain_scores_codex":[0.9941407,0.0003849167,0.0005842791,0.0009208578,0.002510833,0.001458412],"domain_scores_gemma":[0.9951333,0.0001537188,0.0002881722,0.002614026,0.001164329,0.0006464368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002124629,0.0005792846,0.001593432,0.0005956057,0.00008121092,0.000071084,0.0008441447,0.00004313751,0.9746794,0.0001597128,0.009437757,0.01170278],"study_design_scores_gemma":[0.002653402,0.000598487,0.2537116,0.0007412584,0.00004590837,0.000004553799,0.000435159,0.00006215408,0.735476,0.00004737494,0.005953147,0.0002709565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855128,0.002654406,0.00001383229,0.001777354,0.0002535134,0.001447732,0.00008604451,0.00008733177,0.008166997],"genre_scores_gemma":[0.9925117,0.0006890501,0.0001798921,0.0001081062,0.0002887965,0.0003050289,0.00001154842,0.0001167943,0.005789013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2521181,"threshold_uncertainty_score":0.9999465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1113780656270861,"score_gpt":0.3869183949985294,"score_spread":0.2755403293714433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}