{"id":"W2746632276","doi":"10.1158/0008-5472.can-17-0925","title":"Human Pluripotent Stem Cell–Derived <i>TSC2</i> -Haploinsufficient Smooth Muscle Cells Recapitulate Features of Lymphangioleiomyomatosis","year":2017,"lang":"en","type":"article","venue":"Cancer Research","topic":"Tuberous Sclerosis Complex Research","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Esri (Canada); University of Ottawa","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Tehran University of Medical Sciences and Health Services; McGill University Health Centre; University of Ottawa","keywords":"Lymphangioleiomyomatosis; TSC2; Induced pluripotent stem cell; Biology; TSC1; Cancer research; Reprogramming; Haploinsufficiency; Stem cell; Germline mutation; Cell biology; Tuberous sclerosis; Mutation; Cell; Pathology; Genetics; PI3K/AKT/mTOR pathway; Signal transduction; Embryonic stem cell; Phenotype; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001885215,0.000271739,0.0001495278,0.0002251232,0.0001476357,0.000256903,0.0001603292,0.0002689683,0.001044779],"category_scores_gemma":[0.0001083193,0.0001132851,0.0002094579,0.0001119072,0.0002412075,0.0001116141,0.0001494406,0.0005755262,0.0003805136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001501233,"about_ca_system_score_gemma":0.0001408503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005764689,"about_ca_topic_score_gemma":0.0008513802,"domain_scores_codex":[0.9998822,0.00001975041,0.00002409219,0.00002039667,0.00003230416,0.0000212383],"domain_scores_gemma":[0.9998806,0.00002285703,0.00003066974,0.00002222915,0.0000130262,0.00003070761],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002774292,0.00002080196,0.0002774264,0.00001503421,0.000004958341,0.0001176252,0.00002089131,0.0001890147,0.9981907,0.0002792503,0.00006919224,0.0007873849],"study_design_scores_gemma":[0.00002600654,0.0003467027,0.004334995,0.00001007409,0.00002976698,0.000866615,0.00005928584,0.003562611,0.9840919,0.0001161326,0.006547445,0.000008305067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868032,0.0002827722,0.008875742,0.00009914772,0.00004970615,0.0001001777,0.001128921,0.0002139733,0.002446276],"genre_scores_gemma":[0.9933653,0.0002151174,0.00306623,0.00006337524,0.00001025269,0.00007443495,0.0007973252,0.00004904681,0.002358788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001044779,"threshold_uncertainty_score":0.003495157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1113780656270861,"score_gpt":0.3869183949985294,"score_spread":0.2755403293714433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}