{"id":"W2746692142","doi":"10.1128/aac.01044-17","title":"Drug Susceptibility and Replicative Capacity of Multidrug-Resistant Recombinant Human Cytomegalovirus Harboring Mutations in <i>UL56</i> and <i>UL54</i> Genes","year":2017,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Foscarnet; Cidofovir; Virology; Biology; Human cytomegalovirus; Ganciclovir; Recombinant DNA; Mutant; Mutation; Gene; Virus; Cytomegalovirus; Multiple drug resistance; Drug resistance; Herpesviridae; Genetics; Viral disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003740683,0.0002725729,0.0002312472,0.0002836407,0.000142888,0.0002822805,0.0001605469,0.0002710223,0.001331319],"category_scores_gemma":[0.0005626751,0.0001092863,0.0002436976,0.0001640431,0.0001984699,0.000249702,0.0001377873,0.0003578896,0.0002459375],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002184307,"about_ca_system_score_gemma":0.00008971192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005818182,"about_ca_topic_score_gemma":0.0002865834,"domain_scores_codex":[0.9996721,0.0001264815,0.00005514398,0.00004433319,0.00005698197,0.00004498695],"domain_scores_gemma":[0.9995854,0.0001967734,0.00005899004,0.00006165871,0.00004337694,0.00005372893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000373419,0.0001252,0.001777951,0.00002312511,0.00001678208,0.00007482152,0.00004687881,0.0002922528,0.995382,0.00008832701,0.00003974738,0.0017595],"study_design_scores_gemma":[0.00002502938,0.002589779,0.008166378,0.000005288999,0.00002584142,0.0003881871,0.00004702844,0.001777198,0.9864023,0.00003740634,0.0005271973,0.000008359402],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989638,0.000365235,0.0002307501,0.00001284077,0.000007761924,0.000008138027,0.0001235616,0.000009565593,0.0002784732],"genre_scores_gemma":[0.9989763,0.0001261556,0.0003421353,0.000007384482,0.000003368035,0.000009928988,0.0002288307,0.000004702219,0.0003011751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001331319,"threshold_uncertainty_score":0.004453719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03916303286197085,"score_gpt":0.3274002442236926,"score_spread":0.2882372113617218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}