{"id":"W2746704685","doi":"10.1038/s41598-017-10272-7","title":"HIV-1 envelope glycoprotein stimulates viral transcription and increases the infectivity of the progeny virus through the manipulation of cellular machinery","year":2017,"lang":"en","type":"article","venue":"Scientific Reports","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; Centre hospitalier de l'Université Laval; Research Institute in Oncology and Hematology; University of Manitoba","funders":"Canadian Institutes of Health Research; CancerCare Manitoba Foundation; National Institutes of Health; National Natural Science Foundation of China; National Institute of Allergy and Infectious Diseases; Manitoba Health Research Council","keywords":"Infectivity; Glycoprotein; Virology; Virus; Biology; Transcription (linguistics); Viral envelope; Viral entry; Cell biology; Human immunodeficiency virus (HIV); Viral replication; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009557902,0.00021928,0.0002176768,0.0001703225,0.0001539058,0.00034519,0.00008588133,0.0001536347,0.001411842],"category_scores_gemma":[0.0001065521,0.000108056,0.000247765,0.0001310141,0.000177706,0.0001499446,0.0002227597,0.0003196098,0.0002986094],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001793476,"about_ca_system_score_gemma":0.0001176781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001939064,"about_ca_topic_score_gemma":0.0003375634,"domain_scores_codex":[0.9998854,0.00002651712,0.000005855019,0.00002235087,0.00003076219,0.00002905789],"domain_scores_gemma":[0.9999677,0.000008131961,0.000007343827,0.000004508559,0.000003634026,0.000008700666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004947204,0.00001808626,0.0004062216,0.0000437472,0.000004475007,0.00002510614,0.00001207887,0.00004376852,0.996601,0.00009960449,0.00004052891,0.002655903],"study_design_scores_gemma":[0.00001346789,0.0003766846,0.02129132,0.00001735332,0.0000201626,0.0003162355,0.00007972257,0.00105181,0.9701141,0.0001927926,0.006518931,0.000007476066],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829531,0.009894698,0.00337316,0.0001047396,0.00004403052,0.00003083139,0.0004048041,0.00007697801,0.003117723],"genre_scores_gemma":[0.992155,0.003100127,0.00282407,0.00005416397,0.00001998016,0.0000185919,0.0003877858,0.00001204487,0.001428301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001411842,"threshold_uncertainty_score":0.004723132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02144199751991938,"score_gpt":0.2620884757802432,"score_spread":0.2406464782603239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}