{"id":"W2746835184","doi":"10.1002/mds.27105","title":"The nasal and gut microbiome in Parkinson's disease and idiopathic rapid eye movement sleep behavior disorder","year":2017,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":564,"is_retracted":false,"has_abstract":true,"ca_institutions":"Emergent BioSolutions (Canada)","funders":"Deutsche Parkinson Vereinigung; EU Joint Programme – Neurodegenerative Disease Research; Philipps-Universität Marburg; Université du Luxembourg; Fonds National de la Recherche Luxembourg; Michael J. Fox Foundation for Parkinson's Research","keywords":"Rapid eye movement sleep; Microbiome; REM sleep behavior disorder; Disease; Akkermansia muciniphila; Amplicon sequencing; Eye movement; Gut flora; Biology; Medicine; Parkinson's disease; Internal medicine; Immunology; Bioinformatics; Neuroscience; Genetics; 16S ribosomal RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002776426,0.0003596965,0.000332868,0.0001143668,0.0008348105,0.0002207112,0.0002017371,0.00007394916,0.00004270507],"category_scores_gemma":[0.00005482392,0.0002674399,0.0001060624,0.000066933,0.0002969735,0.0001701514,0.0002641471,0.0001554044,0.00000966525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001017232,"about_ca_system_score_gemma":0.00005902856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004227415,"about_ca_topic_score_gemma":0.0007318065,"domain_scores_codex":[0.9981328,0.00005737587,0.0003234063,0.0006126518,0.0003337007,0.0005400893],"domain_scores_gemma":[0.9986261,0.00002207386,0.0001727365,0.0007699073,0.00003109953,0.0003780984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004428345,0.00106243,0.8996298,0.00008951072,0.0001560413,0.0001238155,0.0001611019,0.000001412691,0.001388287,0.0004320711,0.0001549653,0.09635772],"study_design_scores_gemma":[0.005682877,0.0002706535,0.9725393,0.0001098819,0.0002769082,3.384481e-7,0.000360763,0.0002783285,0.0001123461,0.004828736,0.01525567,0.0002841679],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981692,0.0103571,0.0000355471,0.005758907,0.0002202329,0.001499504,0.00006845468,0.00003713038,0.0003311353],"genre_scores_gemma":[0.9919426,0.005103773,0.00006085582,0.00169862,0.00003798684,0.0005936217,0.0000327602,0.00004417527,0.0004856506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09607355,"threshold_uncertainty_score":0.9999778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009455450776109445,"score_gpt":0.2568830981981601,"score_spread":0.2474276474220506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}