{"id":"W2746835184","doi":"10.1002/mds.27105","title":"The nasal and gut microbiome in Parkinson's disease and idiopathic rapid eye movement sleep behavior disorder","year":2017,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":564,"is_retracted":false,"has_abstract":true,"ca_institutions":"Emergent BioSolutions (Canada)","funders":"Deutsche Parkinson Vereinigung; EU Joint Programme – Neurodegenerative Disease Research; Philipps-Universität Marburg; Université du Luxembourg; Fonds National de la Recherche Luxembourg; Michael J. Fox Foundation for Parkinson's Research","keywords":"Rapid eye movement sleep; Microbiome; REM sleep behavior disorder; Disease; Akkermansia muciniphila; Amplicon sequencing; Eye movement; Gut flora; Biology; Medicine; Parkinson's disease; Internal medicine; Immunology; Bioinformatics; Neuroscience; Genetics; 16S ribosomal RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003668811,0.0002070278,0.000342908,0.0006130961,0.0004120378,0.0004983185,0.0001170652,0.0002979056,0.0007005188],"category_scores_gemma":[0.000972297,0.0001158604,0.000195915,0.0004369604,0.0004009895,0.0002935754,0.0005497147,0.0001964514,0.00009493644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003066682,"about_ca_system_score_gemma":0.0002599861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002343402,"about_ca_topic_score_gemma":0.004160296,"domain_scores_codex":[0.9997043,0.00007029176,0.00003460596,0.00007793162,0.00006907619,0.00004381635],"domain_scores_gemma":[0.9996098,0.00006535263,0.0001712697,0.00001844192,0.00006764032,0.00006758197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00106484,0.0000553481,0.9670867,0.00009979735,0.00009042332,0.0005397475,0.0004037211,0.00006734415,0.02109156,0.0000363381,0.00009529508,0.009368869],"study_design_scores_gemma":[0.000006154163,0.0001995455,0.9971867,0.00002118873,0.00002787414,0.001071082,0.0004157388,0.0001096239,0.0006700088,0.0000524153,0.0002367375,0.000002876879],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982979,0.001224839,0.00007976372,0.00002992195,0.000005873445,0.000006025749,0.0001159787,0.000001426439,0.0002383509],"genre_scores_gemma":[0.9991065,0.0003898429,0.0002490593,0.00002993842,0.000006092367,0.00000544368,0.0001469261,0.000001181673,0.00006508853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002343402,"threshold_uncertainty_score":0.004659534,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009455450776109445,"score_gpt":0.2568830981981601,"score_spread":0.2474276474220506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}