{"id":"W2747011695","doi":"10.1016/j.ebiom.2017.08.020","title":"Treatment-Induced Viral Cure of Hepatitis C Virus-Infected Patients Involves a Dynamic Interplay among three Important Molecular Players in Lipid Homeostasis: Circulating microRNA (miR)-24, miR-223, and Proprotein Convertase Subtilisin/Kexin Type 9","year":2017,"lang":"en","type":"article","venue":"EBioMedicine","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Centre for Disease Control; Prairie Women's Health Centre of Excellence; University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"PCSK9; Proprotein convertase; Hepatitis C virus; Virology; Biology; Immunology; Kexin; Hepatitis C; microRNA; Viral load; Virus; LDL receptor; Cholesterol; Lipoprotein; Endocrinology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001941071,0.0002086914,0.0003459374,0.0001855697,0.0002146277,0.0003777349,0.00007735303,0.0001745946,0.0006945365],"category_scores_gemma":[0.0004371152,0.0001215171,0.0001544508,0.000153352,0.0001680575,0.0001377443,0.0001416259,0.0003543909,0.0001563961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001534175,"about_ca_system_score_gemma":0.0001688046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001878743,"about_ca_topic_score_gemma":0.0003575887,"domain_scores_codex":[0.9998192,0.0000529298,0.00001780825,0.00002830374,0.00005011035,0.00003174551],"domain_scores_gemma":[0.999828,0.00003315882,0.00007414106,0.0000112788,0.0000198928,0.00003347056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.003479087,0.0002669187,0.1122592,0.0001099745,0.00008394869,0.0004176715,0.0002177069,0.0004152577,0.8426586,0.0001441406,0.0002053927,0.03974206],"study_design_scores_gemma":[0.0001252648,0.004753944,0.73469,0.00002339794,0.0001459476,0.002734486,0.0003434064,0.003270359,0.2507894,0.0002886551,0.002804265,0.00003084692],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983652,0.0007745553,0.0003651796,0.0000398121,0.000005869205,0.000009711101,0.00004627578,0.00001380446,0.0003796242],"genre_scores_gemma":[0.9990903,0.0001805334,0.0004025512,0.00002256614,0.000008133013,0.00001291779,0.00006473968,0.000002836553,0.0002154514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006945365,"threshold_uncertainty_score":0.002323449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00813404794150855,"score_gpt":0.2576289245218695,"score_spread":0.249494876580361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}