{"id":"W2747011695","doi":"10.1016/j.ebiom.2017.08.020","title":"Treatment-Induced Viral Cure of Hepatitis C Virus-Infected Patients Involves a Dynamic Interplay among three Important Molecular Players in Lipid Homeostasis: Circulating microRNA (miR)-24, miR-223, and Proprotein Convertase Subtilisin/Kexin Type 9","year":2017,"lang":"en","type":"article","venue":"EBioMedicine","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Centre for Disease Control; Prairie Women's Health Centre of Excellence; University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"PCSK9; Proprotein convertase; Hepatitis C virus; Virology; Biology; Immunology; Kexin; Hepatitis C; microRNA; Viral load; Virus; LDL receptor; Cholesterol; Lipoprotein; Endocrinology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001402644,0.0003451199,0.0004296756,0.0001843423,0.0001141026,0.0000375004,0.0002196245,0.0002403577,0.00001648378],"category_scores_gemma":[0.000220889,0.0003061411,0.00009220486,0.0001118461,0.0003168079,0.00002759748,0.0001438733,0.0001162804,0.000001839134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001117355,"about_ca_system_score_gemma":0.0001197551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002891516,"about_ca_topic_score_gemma":0.003863584,"domain_scores_codex":[0.9982458,0.00007320003,0.0005817396,0.0005510368,0.0002111114,0.0003370923],"domain_scores_gemma":[0.9984307,0.00001175157,0.000580118,0.0006673973,0.0001499189,0.0001600887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002735044,0.0002001202,0.325808,0.00007327693,0.0001174601,0.00004903799,0.0001379134,0.000001023247,0.6708574,0.000002111202,0.00002180391,0.002458437],"study_design_scores_gemma":[0.004682833,0.001181132,0.6438329,0.0002950879,0.00009316893,0.0000113477,0.00003749266,0.0011186,0.3483419,0.0000360361,0.00006507841,0.000304415],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972543,0.001254251,0.00006488187,0.00007459841,0.0002069677,0.0009667272,0.0001467962,0.00001649575,0.00001500423],"genre_scores_gemma":[0.998464,0.0001872776,0.0001596489,0.00003064141,0.0000581282,0.00004002151,0.001001067,0.00004658768,0.00001262359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3225154,"threshold_uncertainty_score":0.9999391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00813404794150855,"score_gpt":0.2576289245218695,"score_spread":0.249494876580361,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}