{"id":"W2747084483","doi":"10.1038/nm.4379","title":"Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT–mTORC1 activation","year":2017,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":301,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"National Cancer Institute","keywords":"Bromodomain; BRD4; BET inhibitor; Cancer research; Ubiquitin ligase; Prostate cancer; Biology; mTORC1; Signal transducing adaptor protein; Protein kinase B; Chemistry; Cell biology; Cancer; Ubiquitin; Epigenetics; Biochemistry; Genetics; Gene; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001414091,0.0002398547,0.0002763868,0.0003155713,0.000202551,0.0005837927,0.0002132199,0.0002034159,0.002008981],"category_scores_gemma":[0.0001720404,0.0002183253,0.0002563865,0.0002322442,0.0001901792,0.0001870531,0.0002331505,0.0006708529,0.0003556684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000427009,"about_ca_system_score_gemma":0.0001994834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000335887,"about_ca_topic_score_gemma":0.0007459974,"domain_scores_codex":[0.9998521,0.00001735362,0.00001006483,0.00002529082,0.00004355455,0.00005181339],"domain_scores_gemma":[0.9999194,0.00001230809,0.00002335412,0.00001100912,0.000007989431,0.00002585383],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005511742,0.0001145221,0.003934019,0.00005052158,0.00003555973,0.0003990783,0.00001791546,0.0003843952,0.9849024,0.0008787686,0.0005742472,0.008157452],"study_design_scores_gemma":[0.0001270283,0.0008114512,0.06763863,0.00001201792,0.00007448607,0.005798362,0.00006779822,0.004942858,0.9095398,0.0005657942,0.01040409,0.0000176226],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948758,0.001451107,0.0008615722,0.0002475873,0.00002798548,0.00001679853,0.0004471549,0.000114804,0.00195717],"genre_scores_gemma":[0.9982968,0.0003146246,0.0002560789,0.00003661844,0.000006161807,0.00000842817,0.0002516733,0.00001248302,0.0008171138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002008981,"threshold_uncertainty_score":0.006720662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005170535343120824,"score_gpt":0.2670491265184531,"score_spread":0.2618785911753323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}