{"id":"W2747084483","doi":"10.1038/nm.4379","title":"Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT–mTORC1 activation","year":2017,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":301,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Agency","funders":"National Cancer Institute","keywords":"Bromodomain; BRD4; BET inhibitor; Cancer research; Ubiquitin ligase; Prostate cancer; Biology; mTORC1; Signal transducing adaptor protein; Protein kinase B; Chemistry; Cell biology; Cancer; Ubiquitin; Epigenetics; Biochemistry; Genetics; Gene; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002835868,0.0001895087,0.0002036254,0.00008484823,0.0001492451,0.00003281806,0.0001567455,0.0003871365,0.00003245399],"category_scores_gemma":[0.001061346,0.0001565055,0.00001802415,0.0001427631,0.0001965181,0.00002988144,0.00006427639,0.0003396451,0.000001193141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005594566,"about_ca_system_score_gemma":0.00008368133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001526442,"about_ca_topic_score_gemma":0.0004975154,"domain_scores_codex":[0.9987615,0.00006076078,0.000282772,0.000423466,0.0002668375,0.0002046647],"domain_scores_gemma":[0.9990529,0.0000116498,0.0002751752,0.0003620452,0.000207672,0.00009056048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003475424,0.00003306257,0.007806019,0.00007231132,0.00001810335,0.000002199741,0.0002464895,2.944737e-7,0.9681166,0.00005623748,0.02059806,0.00270309],"study_design_scores_gemma":[0.002495784,0.0001808133,0.01217387,0.0003533814,0.00001034428,6.735453e-7,0.00005645657,0.00001563894,0.9015236,0.0001674496,0.08281376,0.0002081977],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850681,0.003948193,0.0000407957,0.009554834,0.0001870569,0.0008174792,0.00007617052,0.00001895355,0.0002883936],"genre_scores_gemma":[0.9962518,0.0004833466,0.00008366686,0.0007844226,0.0003722484,0.0001048785,0.0007515422,0.00002431616,0.001143763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06659296,"threshold_uncertainty_score":0.6382107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005170535343120824,"score_gpt":0.2670491265184531,"score_spread":0.2618785911753323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}