{"id":"W2747126698","doi":"10.1021/acs.biomac.7b01049","title":"Glycosidase Inhibition by Multivalent Presentation of Heparan Sulfate Saccharides on Bottlebrush Polymers","year":2017,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Roy J. and Lucille A. Carver College of Medicine, University of Iowa; University of North Carolina at Chapel Hill; National Institutes of Health; University of Alberta","keywords":"Heparanase; Chemistry; Heparan sulfate; Glycoside hydrolase; Oligosaccharide; Monomer; Biochemistry; Sulfation; Polymer; Hydrolysis; Stereochemistry; Combinatorial chemistry; Glycosaminoglycan; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001359331,0.0004523556,0.0002069964,0.00009216634,0.00007353241,0.0002912165,0.000186525,0.0002622706,0.0005500197],"category_scores_gemma":[0.0001570786,0.0001023926,0.0002290725,0.0001066885,0.000166516,0.0002333469,0.0001883388,0.0003806211,0.0002237698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001695429,"about_ca_system_score_gemma":0.0001243023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001802028,"about_ca_topic_score_gemma":0.0002911643,"domain_scores_codex":[0.9998997,0.00001928698,0.000005624481,0.00002320396,0.00003389063,0.00001831627],"domain_scores_gemma":[0.9999067,0.00002152953,0.0000337208,0.000009788198,0.00001021506,0.00001804392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002832072,0.0000124952,0.00004386708,0.00002153563,0.000005229177,0.0000200954,0.000005978444,0.0001153764,0.9983175,0.00004954317,0.00001242117,0.001367669],"study_design_scores_gemma":[0.000003178166,0.0002749207,0.0002733576,0.000001730013,0.000008629262,0.00004265922,0.000004636892,0.0003994545,0.9982766,0.00001298,0.0006984602,0.000003286682],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912251,0.001111827,0.006370715,0.00004140012,0.00002599388,0.00002987144,0.00007024066,0.00004680777,0.001077997],"genre_scores_gemma":[0.9902899,0.0008389844,0.006835133,0.00004894875,0.00001381001,0.00002170922,0.0001000976,0.00002004893,0.001831462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005500197,"threshold_uncertainty_score":0.001840055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01632104974884844,"score_gpt":0.3058004877384735,"score_spread":0.289479437989625,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}