{"id":"W2747164725","doi":"10.1371/journal.pgen.1006985","title":"CTCF counter-regulates cardiomyocyte development and maturation programs in the embryonic heart","year":2017,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Heart and Stroke Foundation; Hospital for Sick Children; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Consejería de Educación, Juventud y Deporte, Comunidad de Madrid; Universidad Pablo de Olavide; Hospital for Sick Children; Ministerio de Economía y Competitividad; Heart and Stroke Foundation of Canada; Centro Nacional de Investigaciones Cardiovasculares; Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía","keywords":"CTCF; Biology; Enhancer; Chromatin; Heart development; Cell biology; Regulation of gene expression; Embryonic stem cell; Genetics; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001675584,0.0002525618,0.000287441,0.0003036142,0.0001731303,0.0004999364,0.000280324,0.000301278,0.0009365233],"category_scores_gemma":[0.000206935,0.000153489,0.000190116,0.0001207187,0.0002803152,0.0001738239,0.0003827129,0.0006206938,0.0002773667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004716885,"about_ca_system_score_gemma":0.0003125205,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001372559,"about_ca_topic_score_gemma":0.00259087,"domain_scores_codex":[0.9996295,0.00003594131,0.00002195182,0.0000871513,0.0001302841,0.00009518592],"domain_scores_gemma":[0.9997831,0.000034977,0.00005831448,0.00002950385,0.00002167765,0.00007241848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002436896,0.000008469287,0.0003438768,0.00001274136,0.000002440737,0.00005198478,0.000008811387,0.00003774303,0.9980428,0.0001522473,0.00002883346,0.001285571],"study_design_scores_gemma":[0.00002416745,0.0001168759,0.01517849,0.000007416347,0.00001548643,0.0004148443,0.00003083098,0.001788234,0.9786524,0.0001072081,0.003656461,0.000007515686],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911962,0.001726808,0.004675082,0.0001137572,0.00003687117,0.00001500478,0.0002348656,0.0001815411,0.001820025],"genre_scores_gemma":[0.9965425,0.0003178706,0.0008335492,0.0000433196,0.000005627922,0.00001302382,0.0002215309,0.00003983556,0.001982867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001372559,"threshold_uncertainty_score":0.00342232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0470460313308362,"score_gpt":0.292687787706173,"score_spread":0.2456417563753368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}