{"id":"W2747183034","doi":"10.1016/j.cell.2017.07.037","title":"A Broad-Spectrum Inhibitor of CRISPR-Cas9","year":2017,"lang":"en","type":"article","venue":"Cell","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":270,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; Paul G. Allen Frontiers Group; Paul G. Allen Family Foundation; Howard Hughes Medical Institute; Canadian Institutes of Health Research; Sandler Foundation; National Institutes of Health; National Science Foundation","keywords":"Cas9; CRISPR; Biology; DNA; Genome editing; Computational biology; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000373493,0.0008994396,0.0008573838,0.0007368873,0.0004855553,0.0007817362,0.00117179,0.0008544066,0.003691499],"category_scores_gemma":[0.0002771203,0.0003795379,0.0004827241,0.0004349167,0.0004605958,0.0004410584,0.0005194125,0.001804983,0.002098511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009262643,"about_ca_system_score_gemma":0.0008057131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001706511,"about_ca_topic_score_gemma":0.00424885,"domain_scores_codex":[0.9993568,0.00005399645,0.00006564405,0.0001969148,0.0002310107,0.00009559081],"domain_scores_gemma":[0.9997985,0.00003222094,0.00003918666,0.00004098502,0.00002738653,0.0000616979],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001014025,0.00005359531,0.00007511358,0.00004999264,0.00001608763,0.00005554947,0.000006410596,0.0001198539,0.9940899,0.0004339625,0.0006507092,0.004347272],"study_design_scores_gemma":[0.00001488025,0.00007283843,0.0004978508,0.000005049287,0.00002079755,0.0003558229,0.00000628165,0.0007723004,0.98677,0.0001158321,0.01135752,0.0000108053],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6427965,0.02504165,0.2328596,0.002966841,0.001639222,0.001211922,0.01157465,0.01482619,0.06708328],"genre_scores_gemma":[0.8833131,0.005738589,0.0665455,0.0007647473,0.00006236018,0.000314202,0.005641338,0.0005153663,0.03710477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003691499,"threshold_uncertainty_score":0.01234931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00707313309116966,"score_gpt":0.279499603284483,"score_spread":0.2724264701933133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}