{"id":"W2747295641","doi":"10.1128/mbio.01168-17","title":"TIFA Signaling in Gastric Epithelial Cells Initiates the<i>cag</i>Type 4 Secretion System-Dependent Innate Immune Response to<i>Helicobacter pylori</i>Infection","year":2017,"lang":"en","type":"article","venue":"mBio","topic":"Helicobacter pylori-related gastroenterology studies","field":"Medicine","cited_by":137,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institute of General Medical Sciences; Government of Canada; Fred Hutchinson Cancer Research Center; Howard Hughes Medical Institute","keywords":"Secretion; Pathogen; Innate immune system; Immune system; Inflammation; Helicobacter pylori; Immunology; Helicobacter pylori infection; Biology; Stomach; Microbiology; Helicobacter; Cancer; Human pathogen; Pathogen-associated molecular pattern; Bacteria; Pattern recognition receptor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001187161,0.000324293,0.0002267998,0.0001435114,0.000219094,0.0003165386,0.0001789779,0.0004399899,0.001802408],"category_scores_gemma":[0.00008971646,0.0001066303,0.0004687767,0.00009118766,0.0002067402,0.0002454593,0.0003633671,0.0006969101,0.0009708831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000418284,"about_ca_system_score_gemma":0.0002432558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005491747,"about_ca_topic_score_gemma":0.0005554916,"domain_scores_codex":[0.9998271,0.0000264339,0.000009184867,0.00002626395,0.00002828415,0.00008285332],"domain_scores_gemma":[0.9999238,0.000008459273,0.00001769608,0.00001069066,0.00001270533,0.00002661657],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002256955,0.00002430228,0.0003978586,0.00005755634,0.000003141386,0.0001364001,0.00002038242,0.00003602773,0.9982513,0.0001205644,0.0001328991,0.0005939238],"study_design_scores_gemma":[0.00005279828,0.000632697,0.03484328,0.00003829318,0.00002275074,0.000816086,0.0003288037,0.002209428,0.9527642,0.0002307531,0.008044238,0.00001661955],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890733,0.003313091,0.002470524,0.0005661728,0.0001701061,0.00004013908,0.0008228857,0.0001408483,0.003402961],"genre_scores_gemma":[0.9952263,0.0006330263,0.0009044766,0.0002343252,0.00002945633,0.00003393444,0.0007359762,0.000009488334,0.002193059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001802408,"threshold_uncertainty_score":0.006029665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0196475285694886,"score_gpt":0.2654914474386742,"score_spread":0.2458439188691856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}