{"id":"W2747355438","doi":"10.1096/fj.201700431r","title":"Amyloid‐β and islet amyloid pathologies link Alzheimer’s disease and type 2 diabetes in a transgenic model","year":2017,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto","funders":"National Medical Research Council; National Health and Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Diabetes Canada","keywords":"Islet; Genetically modified mouse; Amyloid (mycology); Endocrinology; Type 2 diabetes; Internal medicine; Transgene; Insulin resistance; Pathogenesis; Alzheimer's disease; Diabetes mellitus; Medicine; Biology; Disease; Pathology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003655543,0.000826258,0.0005138938,0.0008616052,0.0004326406,0.0005834556,0.0005495321,0.0009273995,0.002278647],"category_scores_gemma":[0.0001344877,0.0003207612,0.0005029553,0.0003967514,0.0004325818,0.0006027041,0.0005193323,0.001243479,0.0006368033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003325361,"about_ca_system_score_gemma":0.0004345951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005888958,"about_ca_topic_score_gemma":0.00083472,"domain_scores_codex":[0.9997633,0.00003587753,0.00002404838,0.00005304833,0.00007815608,0.00004554841],"domain_scores_gemma":[0.9998764,0.000007667131,0.00003057446,0.00001524373,0.0000161916,0.00005386525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001594838,0.001607775,0.001718547,0.0003133907,0.00008505605,0.001474517,0.0001272275,0.0001226055,0.9744066,0.003481992,0.001885156,0.01318232],"study_design_scores_gemma":[0.001384556,0.01021699,0.03659375,0.0004222266,0.001007382,0.01622145,0.0004910065,0.005605305,0.7800315,0.009905611,0.1380214,0.00009887537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.935841,0.01984878,0.01518982,0.00336114,0.001078441,0.0004383473,0.001348365,0.0006743036,0.02221966],"genre_scores_gemma":[0.9313214,0.01820474,0.01661365,0.001009104,0.0003148438,0.0006548184,0.001605997,0.00007046426,0.03020491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002278647,"threshold_uncertainty_score":0.007622838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05782990416936639,"score_gpt":0.3240377337831851,"score_spread":0.2662078296138187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}