{"id":"W2747489190","doi":"10.1534/g3.117.300104","title":"Genome-Scale Genetic Interactions and Cell Imaging Confirm Cytokinesis as Deleterious to Transient Topoisomerase II Deficiency in <i>Saccharomyces cerevisiae</i>","year":2017,"lang":"en","type":"article","venue":"G3 Genes Genomes Genetics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"European Regional Development Fund; Danish Agency for Science and Higher Education; Ministerio de Economía y Competitividad; Instituto de Salud Carlos III; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Forsknings- og Innovationsstyrelsen; European Commission; Villum Fonden","keywords":"Biology; Cytokinesis; Mitosis; Mitotic exit; Anaphase; Cell biology; Saccharomyces cerevisiae; Mutation; Genetics; Mitotic catastrophe; Chromatin; Cell cycle; Cell division; Genetic screen; Gene; Mutant; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001339085,0.0003856873,0.0003277303,0.0001508537,0.0005751082,0.000213169,0.0005920587,0.000107911,0.00005221727],"category_scores_gemma":[0.000003163012,0.000416615,0.0001278159,0.00009593793,0.0001200707,0.00001140138,0.0004585091,0.0001136051,0.00001839011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004931771,"about_ca_system_score_gemma":0.0001271561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001443362,"about_ca_topic_score_gemma":0.0007306198,"domain_scores_codex":[0.9979128,0.00004310921,0.0004433912,0.0008139948,0.0001934348,0.0005933294],"domain_scores_gemma":[0.998415,0.000008752847,0.0001855591,0.001000055,0.0001099093,0.000280755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004969062,0.00007949015,0.003009985,0.00003426626,0.00001736912,0.00001263243,0.0004832613,0.0003087596,0.7191958,0.000004708418,0.0000175283,0.2767865],"study_design_scores_gemma":[0.00134842,0.0007096505,0.01279596,0.000028891,0.0001032422,0.0001462957,0.0005155273,0.0002076028,0.4760298,0.0001082231,0.5071284,0.0008779765],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8488521,0.1474834,0.001389869,0.0004953227,0.0003669616,0.0005153321,0.0000714843,0.00001457274,0.0008109462],"genre_scores_gemma":[0.9330643,0.06188923,0.003203612,0.0008459078,0.0002499127,0.00009332952,0.00003328221,0.00006812582,0.0005522295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5071109,"threshold_uncertainty_score":0.9998286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008973956453158578,"score_gpt":0.2568935343662313,"score_spread":0.2479195779130727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}