{"id":"W2747489190","doi":"10.1534/g3.117.300104","title":"Genome-Scale Genetic Interactions and Cell Imaging Confirm Cytokinesis as Deleterious to Transient Topoisomerase II Deficiency in <i>Saccharomyces cerevisiae</i>","year":2017,"lang":"en","type":"article","venue":"G3 Genes Genomes Genetics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"European Regional Development Fund; Danish Agency for Science and Higher Education; Ministerio de Economía y Competitividad; Instituto de Salud Carlos III; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Forsknings- og Innovationsstyrelsen; European Commission; Villum Fonden","keywords":"Biology; Cytokinesis; Mitosis; Mitotic exit; Anaphase; Cell biology; Saccharomyces cerevisiae; Mutation; Genetics; Mitotic catastrophe; Chromatin; Cell cycle; Cell division; Genetic screen; Gene; Mutant; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001058877,0.0003197345,0.0001854995,0.0001965468,0.0001988175,0.0003442887,0.0002603147,0.000297815,0.001436957],"category_scores_gemma":[0.00007321608,0.0001697702,0.0002344463,0.0001849822,0.0002613208,0.000104225,0.0002853438,0.0006707972,0.0003365714],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003941628,"about_ca_system_score_gemma":0.0001230043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00275487,"about_ca_topic_score_gemma":0.003562721,"domain_scores_codex":[0.9998621,0.00001265914,0.000009403459,0.00005172119,0.00003483329,0.00002930595],"domain_scores_gemma":[0.9998094,0.00002944723,0.00004798327,0.00003183974,0.00002436567,0.00005692093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000170891,0.000006468395,0.0001279638,0.000006105073,0.000002274504,0.00001625162,0.000007570438,0.00002340722,0.9995473,0.00003547295,0.00002022339,0.0001899086],"study_design_scores_gemma":[0.000004098958,0.00005472147,0.007290503,0.000002306286,0.000007483144,0.00008096414,0.00002927323,0.0007413356,0.9909034,0.00002565683,0.0008566926,0.000003495088],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899949,0.0005117394,0.005853779,0.00007433593,0.00002722158,0.00001940338,0.001453608,0.0002539491,0.00181105],"genre_scores_gemma":[0.9905626,0.0002821274,0.004764079,0.00006625329,0.000006500019,0.00002803672,0.001279215,0.0001393951,0.002871853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00275487,"threshold_uncertainty_score":0.005477667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008973956453158578,"score_gpt":0.2568935343662313,"score_spread":0.2479195779130727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}