{"id":"W2747599497","doi":"10.1016/j.celrep.2017.07.070","title":"Zscan4 Inhibits Maintenance DNA Methylation to Facilitate Telomere Elongation in Mouse Embryonic Stem Cells","year":2017,"lang":"en","type":"article","venue":"Cell Reports","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Utah Department of Cultural and Community Engagement; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; T.C. İstanbul Kültür Üniversitesi; Health Research; Competence Center Environment and Sustainability; National Institutes of Health; Cancer Research UK; Yale Cancer Center; University of Texas MD Anderson Cancer Center; Cancer Prevention and Research Institute of Texas","keywords":"Telomere; DNA demethylation; Cell biology; Embryonic stem cell; DNA methylation; Biology; DNMT1; Ubiquitin ligase; Telomere-binding protein; Stem cell; Molecular biology; DNA; Genetics; Ubiquitin; Transcription factor; Gene expression; Gene; DNA-binding protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002026381,0.0004336402,0.0002680519,0.0003992384,0.0001854447,0.0003050428,0.0003746154,0.0002827737,0.001622612],"category_scores_gemma":[0.0001067699,0.0002305098,0.0003430613,0.0002617318,0.0002376772,0.0001887024,0.0002337992,0.0006023202,0.0003276299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005420679,"about_ca_system_score_gemma":0.0004882605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009466449,"about_ca_topic_score_gemma":0.001829732,"domain_scores_codex":[0.9998505,0.00001959875,0.00001697214,0.00002589466,0.00004764661,0.00003933419],"domain_scores_gemma":[0.9999154,0.00001127389,0.00002381964,0.00001141834,0.00001058773,0.00002749408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008233299,0.00002071691,0.0001216031,0.00003197721,0.000008998948,0.00001973794,0.000006035112,0.00009395389,0.9982466,0.0001471284,0.00005183676,0.001169149],"study_design_scores_gemma":[0.0000184159,0.0001100142,0.001681357,0.000002615784,0.00001340908,0.00005227993,0.000006716164,0.000594038,0.995452,0.00004121874,0.002025133,0.0000028447],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898907,0.003016539,0.003619205,0.000179075,0.00006618563,0.00004075024,0.0005577017,0.0002533378,0.002376516],"genre_scores_gemma":[0.9900548,0.00147364,0.001964084,0.00009916459,0.00001244336,0.00005942036,0.0009403877,0.00004071034,0.005355343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001622612,"threshold_uncertainty_score":0.005428195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02682907556884787,"score_gpt":0.2656441241731528,"score_spread":0.2388150486043049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}