{"id":"W2747599497","doi":"10.1016/j.celrep.2017.07.070","title":"Zscan4 Inhibits Maintenance DNA Methylation to Facilitate Telomere Elongation in Mouse Embryonic Stem Cells","year":2017,"lang":"en","type":"article","venue":"Cell Reports","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":123,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Utah Department of Cultural and Community Engagement; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; T.C. İstanbul Kültür Üniversitesi; Health Research; Competence Center Environment and Sustainability; National Institutes of Health; Cancer Research UK; Yale Cancer Center; University of Texas MD Anderson Cancer Center; Cancer Prevention and Research Institute of Texas","keywords":"Telomere; DNA demethylation; Cell biology; Embryonic stem cell; DNA methylation; Biology; DNMT1; Ubiquitin ligase; Telomere-binding protein; Stem cell; Molecular biology; DNA; Genetics; Ubiquitin; Transcription factor; Gene expression; Gene; DNA-binding protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007498654,0.0001897428,0.0001968529,0.0001066348,0.000174682,0.00009480211,0.0002565748,0.0001708037,0.00001314996],"category_scores_gemma":[0.0001181472,0.0001901266,0.00008069722,0.00008086988,0.00006214491,0.00001870993,0.0002761166,0.0001455818,0.00007507018],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008549356,"about_ca_system_score_gemma":0.0001354238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001058487,"about_ca_topic_score_gemma":0.0002225785,"domain_scores_codex":[0.9980903,0.00008468588,0.0004067559,0.000672195,0.0003056649,0.0004404408],"domain_scores_gemma":[0.9982163,0.00001197025,0.0003026265,0.001140164,0.0001588043,0.000170129],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003982356,0.00004324638,0.002904955,0.00005356436,0.000008285242,0.0001268257,0.00007563171,0.0004784583,0.9914861,0.000002191348,0.001857196,0.00292369],"study_design_scores_gemma":[0.0002742615,0.00009197113,0.004505886,0.00002793975,0.000003707576,0.00002028576,0.00005435198,0.00006718339,0.978597,0.00002550345,0.01611554,0.000216405],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928251,0.0002065432,0.0004479685,0.0001811853,0.0002320401,0.0005835764,0.00001339141,0.00001460338,0.0054956],"genre_scores_gemma":[0.953146,0.0001336322,0.0001833464,0.00004470186,0.00005671506,0.00005108084,0.00004401512,0.00002838154,0.04631211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04081651,"threshold_uncertainty_score":0.7753137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02682907556884787,"score_gpt":0.2656441241731528,"score_spread":0.2388150486043049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}