{"id":"W2747687728","doi":"10.2165/11530800-000000000-00000","title":"Subjective Effects and Safety of Whole and Tampered Morphine Sulfate and Naltrexone Hydrochloride (ALO-01) Extended-Release Capsules versus Morphine Solution and Placebo in Experienced Non-Dependent Opioid Users","year":2009,"lang":"en","type":"article","venue":"Clinical Drug Investigation","topic":"Opioid Use Disorder Treatment","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Johnson and Johnson","keywords":"Morphine; Placebo; Euphoriant; Medicine; Anesthesia; Visual analogue scale; Opioid; Oxycodone; Naltrexone; Crossover study; Heroin; Pharmacology; Internal medicine; Drug; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006271331,0.0003897777,0.0004900731,0.0001759642,0.000201734,0.0002923175,0.0002360285,0.0003974976,0.003173276],"category_scores_gemma":[0.002019352,0.0002781466,0.0004582052,0.0001509875,0.000404651,0.0005623199,0.00017134,0.0006004585,0.0002818967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001581585,"about_ca_system_score_gemma":0.0001536727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007358785,"about_ca_topic_score_gemma":0.001218465,"domain_scores_codex":[0.9996998,0.0001484386,0.00003436019,0.00003115926,0.00004760746,0.00003866946],"domain_scores_gemma":[0.9985681,0.0005911674,0.0002960465,0.00008013524,0.0000979633,0.0003665512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.653271,0.02485699,0.09981814,0.0007454525,0.0008295125,0.0007567035,0.001577497,0.00108852,0.1374508,0.0002356122,0.0004705812,0.07889917],"study_design_scores_gemma":[0.01851729,0.4303678,0.5244727,0.00003708371,0.0006729786,0.0008504165,0.001082917,0.002567499,0.02050918,0.0001125307,0.0007091726,0.0001003999],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995303,0.0001364625,0.00003819928,0.000009139002,0.000006330378,0.00001663074,0.00005045191,0.000002692328,0.0002098151],"genre_scores_gemma":[0.9991999,0.000112779,0.00008144085,0.00002142002,0.00001882419,0.00001263653,0.0000504248,0.000001324788,0.0005012583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003173276,"threshold_uncertainty_score":0.01061565,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01725757387396902,"score_gpt":0.2982667005313795,"score_spread":0.2810091266574105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}