{"id":"W2747687728","doi":"10.2165/11530800-000000000-00000","title":"Subjective Effects and Safety of Whole and Tampered Morphine Sulfate and Naltrexone Hydrochloride (ALO-01) Extended-Release Capsules versus Morphine Solution and Placebo in Experienced Non-Dependent Opioid Users","year":2009,"lang":"en","type":"article","venue":"Clinical Drug Investigation","topic":"Opioid Use Disorder Treatment","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Johnson and Johnson","keywords":"Morphine; Placebo; Euphoriant; Medicine; Anesthesia; Visual analogue scale; Opioid; Oxycodone; Naltrexone; Crossover study; Heroin; Pharmacology; Internal medicine; Drug; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006136888,0.0003013383,0.0006503894,0.0001674679,0.0001070717,0.00002434122,0.00005009534,0.0001768783,0.000003187677],"category_scores_gemma":[0.001148324,0.0002736467,0.00004697414,0.0002079707,0.0006460525,0.0002788259,0.00007215545,0.0003019666,0.000002742913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009545726,"about_ca_system_score_gemma":0.0001157542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000469055,"about_ca_topic_score_gemma":0.0001688388,"domain_scores_codex":[0.9978667,0.0001775639,0.0007379075,0.0006608165,0.0002801176,0.000276864],"domain_scores_gemma":[0.9983601,0.0006410379,0.0002529919,0.0002528212,0.00007913587,0.0004139361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02591002,0.001938859,0.6419762,0.001367862,0.0004006067,0.0002246241,0.02423229,0.0001501039,0.2688015,0.0004536927,0.0002001016,0.03434413],"study_design_scores_gemma":[0.02114099,0.0015546,0.9464189,0.0004865662,0.0001931773,0.0000180173,0.001140519,0.006548349,0.02098563,0.001262059,0.000007370168,0.0002437608],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952263,0.001338541,0.0000509043,0.001896255,0.0001399324,0.001251978,0.00002764132,0.00003670103,0.00003180643],"genre_scores_gemma":[0.9964765,0.001994221,0.001039107,0.0002093719,0.00006463798,0.00005349044,0.0001099215,0.00002086338,0.00003182764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3044428,"threshold_uncertainty_score":0.9999716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01725757387396902,"score_gpt":0.2982667005313795,"score_spread":0.2810091266574105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}