{"id":"W2747905863","doi":"10.1158/1535-7163.mct-17-0292","title":"Estrogen Receptor β Is a Novel Target in Acute Myeloid Leukemia","year":2017,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Grand River Hospital; University of Guelph; Regional Municipality of Waterloo; Ontario Institute for Cancer Research; University of Waterloo","funders":"","keywords":"Myeloid leukemia; Estrogen receptor; Leukemia; Cancer research; Haematopoiesis; Gene knockdown; Pharmacology; Biology; Myeloid; Stem cell; Cell culture; Cancer; Immunology; Cell biology; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001926288,0.0003004502,0.0003396544,0.0002812883,0.0001338355,0.0003602928,0.0002381579,0.0002742015,0.001405888],"category_scores_gemma":[0.0001327816,0.000114627,0.0002001947,0.0003523363,0.0001121173,0.0001613777,0.0002121971,0.0004268578,0.0006570989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003809289,"about_ca_system_score_gemma":0.0002403477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003299513,"about_ca_topic_score_gemma":0.000759453,"domain_scores_codex":[0.9999131,0.00001240273,0.000006990213,0.0000183587,0.00003574287,0.00001331925],"domain_scores_gemma":[0.9999574,0.000007988332,0.00001091598,0.000004904742,0.000009296688,0.000009409918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002788047,0.000103209,0.002696078,0.0003622551,0.00004041222,0.0004853478,0.00002569049,0.0005468428,0.9375037,0.0006457122,0.001787331,0.05552449],"study_design_scores_gemma":[0.000195429,0.001113229,0.01533054,0.00006772597,0.0001974267,0.004592035,0.00007296225,0.002384309,0.8224016,0.000732925,0.152896,0.00001592878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8602745,0.1038364,0.01257217,0.002245303,0.000304493,0.0003480173,0.002680856,0.0004127679,0.01732555],"genre_scores_gemma":[0.9484568,0.03360875,0.00476884,0.000685104,0.00006758342,0.00008543167,0.002749875,0.00002322237,0.009554457],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001405888,"threshold_uncertainty_score":0.004703164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01367495319775981,"score_gpt":0.2825024646678262,"score_spread":0.2688275114700664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}