{"id":"W2748196056","doi":"10.1096/fj.201700292rr","title":"Quantitative assessment of the degradation of aggregated TDP‐43 mediated by the ubiquitin proteasome system and macroautophagy","year":2017,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Accademia Nazionale dei Lincei; University of British Columbia","keywords":"Proteasome; Frontotemporal lobar degeneration; Ubiquitin; Neurodegeneration; Autophagy; Cytosol; Protein degradation; Cell biology; Protein aggregation; Degradation (telecommunications); Chemistry; Amyotrophic lateral sclerosis; Biology; Biochemistry; Frontotemporal dementia; Gene; Apoptosis; Medicine; Disease; Enzyme; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001636126,0.0001140158,0.0002704199,0.00003677654,0.0006331769,0.00008155713,0.0005088073,0.00005745569,0.00005188083],"category_scores_gemma":[0.0004575748,0.00004416747,0.00008560488,0.0001034523,0.0005901814,0.0001174601,0.0001598225,0.0005225302,0.000002449143],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001108509,"about_ca_system_score_gemma":0.0002061986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002634572,"about_ca_topic_score_gemma":0.00001320602,"domain_scores_codex":[0.9980119,0.000528403,0.0003912597,0.0001105809,0.00074575,0.0002121395],"domain_scores_gemma":[0.9980496,0.0002232729,0.0008302927,0.0004910755,0.0003171369,0.00008859885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002601532,0.00007334274,0.01747205,0.0001255403,0.0002441857,0.00001174246,0.0004936764,0.00001045401,0.9779422,0.001097189,0.0004362693,0.001833205],"study_design_scores_gemma":[0.002907081,0.0007047593,0.7373291,0.001362309,0.0001942243,0.000430503,0.001505153,0.009875019,0.2453861,0.0001348823,0.00006390836,0.0001069869],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992331,0.0004054811,0.0001447619,0.005842165,0.00009265658,0.000736414,0.00003618209,0.000007427714,0.0004039302],"genre_scores_gemma":[0.9989626,0.0001467007,0.0001495982,0.00004544332,0.00004983492,0.00001618622,0.000004367059,0.0000135403,0.0006117642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7325561,"threshold_uncertainty_score":0.4869949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04081632069893261,"score_gpt":0.3383264327294315,"score_spread":0.2975101120304989,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}