{"id":"W2748215501","doi":"10.1172/jci94031","title":"Mice expressing KrasG12D in hematopoietic multipotent progenitor cells develop neonatal myeloid leukemia","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute; National Cancer Institute; National Institutes of Health; University of Toronto; School of Medicine, Indiana University; Riley Children's Foundation","keywords":"Juvenile myelomonocytic leukemia; Progenitor cell; Biology; Myeloid; Haematopoiesis; Cancer research; Immunology; Stem cell; Cell biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002246924,0.0006411604,0.0002431649,0.0008347195,0.0002840916,0.0002972021,0.0004680041,0.000605843,0.003044436],"category_scores_gemma":[0.0001151126,0.0002709983,0.0002298731,0.0002464019,0.0005396035,0.0002934388,0.0003796479,0.0008610483,0.001033606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004392754,"about_ca_system_score_gemma":0.0003400323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004627976,"about_ca_topic_score_gemma":0.00147337,"domain_scores_codex":[0.9997116,0.00004695519,0.00004130938,0.0000502212,0.0001009158,0.00004889939],"domain_scores_gemma":[0.9997925,0.00002116254,0.00006999839,0.00001926443,0.00001342115,0.00008358861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003722847,0.0001571628,0.0008008032,0.00008906006,0.00001198133,0.000525591,0.00005837588,0.0002376822,0.9883628,0.00131145,0.000408343,0.007664359],"study_design_scores_gemma":[0.0001587783,0.000920948,0.006327278,0.00004988298,0.00003539413,0.003021706,0.0001053339,0.001737413,0.9604402,0.0003296592,0.02685321,0.00002020967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9672402,0.001811166,0.01784113,0.0008214572,0.0001510365,0.0002954588,0.003360726,0.001263263,0.007215565],"genre_scores_gemma":[0.958952,0.001912598,0.01656064,0.0002722013,0.00002432665,0.0002996546,0.002432768,0.0001766043,0.01936927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003044436,"threshold_uncertainty_score":0.01018465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09245152628540647,"score_gpt":0.3966234018853487,"score_spread":0.3041718755999422,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}