{"id":"W2748227909","doi":"10.1016/j.exphem.2017.06.301","title":"Generation of a new, human growth factor-dependent, de novo model of AML from c-MYC-transduced normal human CD34+ hematopoietic cells","year":2017,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Haematopoiesis; CD34; Myeloid leukemia; Biology; Bone marrow; Leukemia; Cancer research; Myeloid; CD33; Progenitor cell; Stromal cell; Cord blood; Immunology; Stem cell; Molecular biology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001251141,0.0002612964,0.0007667398,0.0001519381,0.000230478,0.00002601951,0.0004243344,0.0002537555,0.0034881],"category_scores_gemma":[0.00001564566,0.0002630771,0.0002134882,0.00004279609,0.0003448472,0.0001477783,0.0001505304,0.0002489531,0.00001749123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001298921,"about_ca_system_score_gemma":0.0001621818,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001604015,"about_ca_topic_score_gemma":0.0001717706,"domain_scores_codex":[0.9980311,0.00007082982,0.0005983587,0.0004200016,0.0004437529,0.0004359001],"domain_scores_gemma":[0.9984845,0.00003273732,0.0003029456,0.0008484084,0.0000944792,0.0002369148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002504109,0.0005591973,0.007734164,0.00008701735,0.0001272943,0.00004699429,0.004133958,0.00000699032,0.9816036,0.005209959,0.0001953573,0.00004501969],"study_design_scores_gemma":[0.003956473,0.0004799579,0.0006855785,0.0000570443,0.00003795729,0.0001043643,0.0003751248,0.0007078451,0.9929166,0.0004824322,0.000008655094,0.0001879427],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948722,0.000519608,0.0006238602,0.0001010582,0.0001290744,0.0005003999,0.00004218471,0.00003390379,0.003177701],"genre_scores_gemma":[0.9964675,0.00001389767,0.001154678,0.00005482828,0.0001567435,0.00003120119,0.00006741776,0.00005436112,0.001999414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01131299,"threshold_uncertainty_score":0.9999821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1093038196477219,"score_gpt":0.3848264903160769,"score_spread":0.275522670668355,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}