{"id":"W2748331328","doi":"10.1111/hae.13320","title":"Immunogenicity, efficacy and safety of Nuwiq<sup>®</sup> (human‐cl rh<scp>FVIII</scp>) in previously untreated patients with severe haemophilia A—Interim results from the NuProtect Study","year":2017,"lang":"en","type":"article","venue":"Haemophilia","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; Ontario Clinical Oncology Group; Hospital for Sick Children; McMaster University; McMaster Children's Hospital; University of Alberta Hospital; University of Alberta","funders":"","keywords":"Medicine; Immunogenicity; Haemophilia; Tolerability; Interim analysis; Haemophilia A; Internal medicine; Cumulative incidence; Confidence interval; Incidence (geometry); Adverse effect; Clinical trial; Surgery; Cohort; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009740936,0.0006793305,0.001254659,0.0002285802,0.0008728483,0.000174321,0.0009426035,0.0002989261,0.00006075081],"category_scores_gemma":[0.001601858,0.0004141229,0.000187755,0.0003526567,0.0007985514,0.0002850459,0.000718754,0.0008505419,0.00005881776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002274797,"about_ca_system_score_gemma":0.000211863,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004806655,"about_ca_topic_score_gemma":0.000783999,"domain_scores_codex":[0.9953189,0.0004398581,0.001100858,0.001142837,0.001109415,0.0008881011],"domain_scores_gemma":[0.9952901,0.0007585473,0.0005379235,0.002680226,0.0004020959,0.0003310911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007808784,0.004498058,0.9610184,0.0001587668,0.001319858,0.0005664776,0.01248393,0.00004684613,0.0007030649,0.00001944558,0.001042692,0.01033367],"study_design_scores_gemma":[0.04127596,0.003970175,0.9497652,0.001170305,0.0004252296,0.00003367119,0.0009943582,0.000148134,0.00141409,0.000123102,0.0004380541,0.0002416989],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891934,0.0004223431,0.000001314695,0.000860226,0.00007290921,0.006090357,0.0003826349,0.00008034973,0.002896463],"genre_scores_gemma":[0.9968071,0.0001640756,0.00008551306,0.00006256406,0.0001649841,0.0001043859,0.0003578377,0.00009649216,0.002157025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03346718,"threshold_uncertainty_score":0.9998311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03174979051377812,"score_gpt":0.3008863796132489,"score_spread":0.2691365890994707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}