{"id":"W2748331328","doi":"10.1111/hae.13320","title":"Immunogenicity, efficacy and safety of Nuwiq<sup>®</sup> (human‐cl rh<scp>FVIII</scp>) in previously untreated patients with severe haemophilia A—Interim results from the NuProtect Study","year":2017,"lang":"en","type":"article","venue":"Haemophilia","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; Ontario Clinical Oncology Group; Hospital for Sick Children; McMaster University; McMaster Children's Hospital; University of Alberta Hospital; University of Alberta","funders":"","keywords":"Medicine; Immunogenicity; Haemophilia; Tolerability; Interim analysis; Haemophilia A; Internal medicine; Cumulative incidence; Confidence interval; Incidence (geometry); Adverse effect; Clinical trial; Surgery; Cohort; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002977702,0.0003415162,0.0005338803,0.0002402071,0.0001870699,0.0005008206,0.0002463519,0.000389667,0.0005372928],"category_scores_gemma":[0.001755702,0.0002108553,0.0006929467,0.0002272036,0.0003499262,0.0004807967,0.0002795044,0.0005314709,0.0001841624],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003960674,"about_ca_system_score_gemma":0.0002759279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004269559,"about_ca_topic_score_gemma":0.0003147502,"domain_scores_codex":[0.9990791,0.0004515718,0.00007237521,0.00009567687,0.0002111408,0.00009001092],"domain_scores_gemma":[0.998512,0.0003468247,0.0006210532,0.00013664,0.0001105279,0.0002728474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1043719,0.004732623,0.7592369,0.0002520809,0.0008607239,0.0005250392,0.0006751101,0.001706916,0.04183046,0.0001535272,0.001071165,0.08458363],"study_design_scores_gemma":[0.002950975,0.165796,0.8195203,0.00002514026,0.0003101793,0.0009255157,0.000102187,0.0008042047,0.008216523,0.00003467417,0.001294719,0.00001966593],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991919,0.0004360249,0.00005953408,0.00001685385,0.000002531343,0.00002443444,0.00006565132,0.000003413332,0.0001996379],"genre_scores_gemma":[0.9992724,0.0001352672,0.0001040622,0.00002753431,0.00001092331,0.00001926529,0.0002810448,0.000001442314,0.0001480018],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002977702,"threshold_uncertainty_score":0.01574779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03174979051377812,"score_gpt":0.3008863796132489,"score_spread":0.2691365890994707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}