{"id":"W2748380502","doi":"10.1186/s12974-017-0944-0","title":"Prophylactic inhibition of neutrophil elastase prevents the development of chronic neuropathic pain in osteoarthritic mice","year":2017,"lang":"en","type":"article","venue":"Journal of Neuroinflammation","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; Nova Scotia Health Research Foundation; Arthritis Society","keywords":"Neutrophil elastase; Medicine; Elastase; Inflammation; Osteoarthritis; Edema; Internal medicine; Joint pain; Neuropathic pain; Systemic inflammation; Anesthesia; Endocrinology; Immunology; Pathology; Chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001715104,0.0001021247,0.0002500557,0.0001505283,0.00009632625,0.00001635711,0.0001036791,0.00003928918,0.000006225509],"category_scores_gemma":[0.0009256019,0.00007073252,0.00008062242,0.00006761888,0.00004453116,0.0002321656,0.00002991333,0.0001994932,0.000002309526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008903486,"about_ca_system_score_gemma":0.0003380364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003267271,"about_ca_topic_score_gemma":0.00002142572,"domain_scores_codex":[0.9983102,0.0003536324,0.0007683939,0.00009004287,0.000361202,0.0001164942],"domain_scores_gemma":[0.998086,0.0001229721,0.001341657,0.0002357282,0.0001656894,0.00004790812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003276324,0.0003341491,0.001581278,0.0005220205,0.00002208197,0.0002084931,0.0004523651,0.0001102981,0.9241105,0.00004195893,0.000002685447,0.07228651],"study_design_scores_gemma":[0.007363962,0.00466049,0.2847539,0.00247493,0.000208339,0.0003895293,0.0001201112,0.002204501,0.6967717,0.000833762,0.00007507481,0.000143663],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983672,0.0001003185,0.0005522773,0.000459348,0.0001163617,0.0003562076,0.000001139421,0.000002537418,0.00004462004],"genre_scores_gemma":[0.9992291,0.0000335203,0.0006159449,0.00001039047,0.00007764466,0.000004763221,0.000002304014,0.00001203559,0.00001428094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2831726,"threshold_uncertainty_score":0.2884389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01919924183088831,"score_gpt":0.2683446513977901,"score_spread":0.2491454095669018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}