{"id":"W2748399793","doi":"10.1016/j.celrep.2018.05.016","title":"Primary Cilia Mediate Diverse Kinase Inhibitor Resistance Mechanisms in Cancer","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Universität zu Köln; Imperial College London; Royal Society; Cancer Research UK; Cancer Research UK Cambridge Institute, University of Cambridge; Wellcome Trust; University of Greenwich; Sarcoma UK; University of Toronto; Memorial Sloan-Kettering Cancer Center","keywords":"Cilium; Ciliogenesis; Smoothened; Microtubule; Cell biology; Biology; Intraflagellar transport; Centrosome; Hedgehog signaling pathway; Hedgehog; Kinase; Signal transduction; Flagellum; Cancer; Genetics; Gene; Cell cycle","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001320644,0.0001398202,0.0001290746,0.00003461459,0.0000554875,0.00001216185,0.00008761435,0.000112039,0.0001188202],"category_scores_gemma":[0.000063216,0.0001364119,0.00005956372,0.00008325476,0.00009469414,0.000002981865,0.0001126786,0.00004840691,0.00001491894],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003024608,"about_ca_system_score_gemma":0.0002634398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004323082,"about_ca_topic_score_gemma":0.0002555808,"domain_scores_codex":[0.998873,0.00002967361,0.0002477992,0.000436245,0.0001623204,0.0002509734],"domain_scores_gemma":[0.9992175,0.000003455405,0.000120878,0.0004078168,0.00008598137,0.0001643925],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008382322,0.00009357979,0.004199564,0.00004946496,0.000009262522,0.0003386557,0.00004981173,0.000003441082,0.9674093,0.000003823919,0.02744764,0.0003116089],"study_design_scores_gemma":[0.0003635313,0.00009687135,0.01068073,0.00003558144,0.00002130805,0.000008978168,0.00005483856,0.000001833762,0.917617,0.0004543104,0.07043841,0.0002266009],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869514,0.001970893,0.0001673709,0.00006609436,0.0007430053,0.000190265,0.00002235531,0.00001405403,0.00987453],"genre_scores_gemma":[0.9912345,0.0002323008,0.0005923301,0.0005083067,0.0003698162,0.00004162081,0.00008054119,0.0000197392,0.006920785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04979232,"threshold_uncertainty_score":0.5562716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007083382095137371,"score_gpt":0.2284707732482956,"score_spread":0.2213873911531583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}