{"id":"W2748399793","doi":"10.1016/j.celrep.2018.05.016","title":"Primary Cilia Mediate Diverse Kinase Inhibitor Resistance Mechanisms in Cancer","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Universität zu Köln; Imperial College London; Royal Society; Cancer Research UK; Cancer Research UK Cambridge Institute, University of Cambridge; Wellcome Trust; University of Greenwich; Sarcoma UK; University of Toronto; Memorial Sloan-Kettering Cancer Center","keywords":"Cilium; Ciliogenesis; Smoothened; Microtubule; Cell biology; Biology; Intraflagellar transport; Centrosome; Hedgehog signaling pathway; Hedgehog; Kinase; Signal transduction; Flagellum; Cancer; Genetics; Gene; Cell cycle","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002598892,0.0001775123,0.0003684203,0.0003579818,0.0003166313,0.0005582152,0.0001981534,0.0003906676,0.0009452448],"category_scores_gemma":[0.0001691606,0.0001464869,0.0002552711,0.0001488067,0.0004581209,0.0003156607,0.000464211,0.0003802459,0.0002728509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004673955,"about_ca_system_score_gemma":0.000245203,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006540396,"about_ca_topic_score_gemma":0.0009409506,"domain_scores_codex":[0.9998391,0.00002332651,0.00001225462,0.00002267242,0.00004930585,0.00005331284],"domain_scores_gemma":[0.9998823,0.00001576816,0.00003479727,0.00001666264,0.00001529189,0.0000351281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000327661,0.00005512857,0.004176348,0.0001878768,0.00002819847,0.0007215114,0.000133892,0.0001852383,0.9805303,0.001558064,0.0003495984,0.0117462],"study_design_scores_gemma":[0.00005368847,0.0006695254,0.07480672,0.00003753117,0.000141477,0.003764407,0.0002770342,0.001322405,0.8965647,0.001071058,0.02126135,0.00003015289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9706013,0.02218819,0.002403286,0.0004571528,0.00004975395,0.00003222307,0.0001620737,0.0001344826,0.003971424],"genre_scores_gemma":[0.9927684,0.005156783,0.0004454211,0.00007640764,0.00001498226,0.00001130261,0.00008495485,0.000008778004,0.001432848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009452448,"threshold_uncertainty_score":0.003391147,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007083382095137371,"score_gpt":0.2284707732482956,"score_spread":0.2213873911531583,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}