{"id":"W2748400555","doi":"10.1056/nejmoa1707914","title":"Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease","year":2017,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9109,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Canakinumab; Medicine; Placebo; Myocardial infarction; Hazard ratio; Internal medicine; Confidence interval; Randomized controlled trial; Clinical endpoint; C-reactive protein; Surgery; Gastroenterology; Inflammation; Disease; Pathology; Anakinra","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000693735,0.0003518013,0.0007574272,0.0003834623,0.0002176658,0.0003656517,0.0002914806,0.0004288478,0.003063376],"category_scores_gemma":[0.0007049009,0.00008842434,0.0004089785,0.0002889732,0.0003074401,0.0002241354,0.0002131362,0.0008960466,0.0006743676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000270044,"about_ca_system_score_gemma":0.0004078849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001738369,"about_ca_topic_score_gemma":0.0003453194,"domain_scores_codex":[0.9997194,0.0001021426,0.00003565703,0.00003357177,0.00007041958,0.00003875846],"domain_scores_gemma":[0.9996949,0.00008404011,0.00008540248,0.00002523895,0.00003384771,0.00007656261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.04896807,0.008685522,0.008786906,0.006009846,0.001388742,0.001542819,0.0001684738,0.001020271,0.1375947,0.001781341,0.01113187,0.7729213],"study_design_scores_gemma":[0.2493529,0.3096035,0.09684275,0.002889254,0.004738525,0.01566797,0.0002054568,0.004152752,0.09490213,0.004907693,0.2166075,0.0001295329],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7362105,0.2353158,0.002862458,0.003745853,0.001770444,0.001446691,0.0002332696,0.0002882828,0.0181267],"genre_scores_gemma":[0.9551343,0.03509481,0.002224506,0.002320867,0.001087727,0.0006121819,0.0002126548,0.00001339527,0.003299524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003063376,"threshold_uncertainty_score":0.01024801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01683589248186131,"score_gpt":0.2681017057267959,"score_spread":0.2512658132449346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}