{"id":"W2748475235","doi":"10.1139/cjc-2017-0380","title":"Analysis of the interaction between the cocaine-binding aptamer and its ligands using fluorescence spectroscopy","year":2017,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"","keywords":"Chemistry; Quenching (fluorescence); Fluorescence; Aptamer; Binding constant; Fluorescence spectroscopy; Ligand (biochemistry); Stacking; Spectroscopy; Binding site; Photochemistry; Biophysics; Biochemistry; Organic chemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002678858,0.00029527,0.0004171032,0.0002159581,0.0003054922,0.000238853,0.0003332035,0.000469466,0.001280564],"category_scores_gemma":[0.0004933308,0.0001313147,0.0002158055,0.00019625,0.000164794,0.0002110639,0.0001634957,0.0005735712,0.0004355365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003319599,"about_ca_system_score_gemma":0.0002168461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00127203,"about_ca_topic_score_gemma":0.00140859,"domain_scores_codex":[0.9997067,0.00004933478,0.00001069484,0.00006665351,0.0001097844,0.00005677651],"domain_scores_gemma":[0.9997236,0.0001165163,0.00003826647,0.00001289889,0.00005805007,0.00005067154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002832117,0.00001591857,0.0002718953,0.00001238136,0.000005276928,0.00002260552,0.0000134964,0.0001041113,0.9986542,0.00006264884,0.00001292632,0.0007961923],"study_design_scores_gemma":[0.000003386296,0.00008377859,0.003036607,0.000002666312,0.000008620532,0.00009652314,0.00001704182,0.004953751,0.9910339,0.0000575993,0.0007003278,0.00000579812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9596447,0.0009494087,0.03662615,0.0001206476,0.00001966438,0.00005584398,0.0001858383,0.0001212507,0.002276397],"genre_scores_gemma":[0.9753194,0.0004046065,0.02122884,0.0001193461,0.000007354211,0.00007186205,0.0002920584,0.00003273247,0.002523792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001280564,"threshold_uncertainty_score":0.004283965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0168141181950822,"score_gpt":0.2923720706121777,"score_spread":0.2755579524170955,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}