{"id":"W2748481024","doi":"10.1155/2017/3062892","title":"<i>In Vitro</i>Immunomodulatory Activity of a Transition-State Analog Inhibitor of Human Purine Nucleoside Phosphorylase in Cutaneous Leishmaniasis","year":2017,"lang":"en","type":"article","venue":"Journal of Immunology Research","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ministry of Health, British Columbia; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Purine nucleoside phosphorylase; Nucleoside analogue; In vitro; Purine analogue; Purine; Nucleoside; Transition state analog; Pharmacology; Cutaneous leishmaniasis; Chemistry; Virology; Leishmaniasis; Medicine; Biochemistry; Enzyme; Immunology; Active site","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001588427,0.00022228,0.0001519891,0.0001002382,0.00008234947,0.0001383717,0.0001508858,0.0001499904,0.001516018],"category_scores_gemma":[0.000115496,0.00006627815,0.0002086182,0.0001059967,0.00007887322,0.00009459403,0.00008568681,0.0003564874,0.0002836318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009458844,"about_ca_system_score_gemma":0.00009869935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003349332,"about_ca_topic_score_gemma":0.0003747706,"domain_scores_codex":[0.9998996,0.00004511854,0.000008881597,0.00001124022,0.0000119391,0.0000231642],"domain_scores_gemma":[0.9999495,0.0000160496,0.000009685922,0.0000061764,0.00000723146,0.00001139021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001709258,0.0006109941,0.0003029778,0.0001861806,0.00002362285,0.00009833584,0.00002639379,0.0003685007,0.9910164,0.00007430733,0.0003244586,0.005258666],"study_design_scores_gemma":[0.0004261624,0.01178552,0.004447463,0.00002263486,0.00007090369,0.0002888309,0.00002549686,0.001579711,0.977268,0.00005147227,0.004026368,0.000007318347],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933476,0.003261907,0.0006725412,0.0001043369,0.0000822525,0.00005905646,0.0003237816,0.00003133209,0.002117049],"genre_scores_gemma":[0.9954097,0.001427938,0.000841514,0.0001310392,0.00004697114,0.00006358384,0.0009109146,0.000007002735,0.001161336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001516018,"threshold_uncertainty_score":0.00507158,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04307714814078433,"score_gpt":0.3749568938902897,"score_spread":0.3318797457495054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}