{"id":"W2748607562","doi":"10.1371/journal.pone.0182999","title":"Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk","year":2017,"lang":"en","type":"article","venue":"PLoS ONE","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Heart, Lung, and Blood Institute; Medical Research Council; Tays; Universität Ulm; Technische Universität München; Medizinischen Hochschule Hannover; Università degli Studi dell'Insubria; Université de Toulouse; Háskóli Íslands; Landspítali Háskólasjúkrahús; Kuopion Yliopistollinen Sairaala; Universitätsmedizin der Johannes Gutenberg-Universität Mainz; Queen's University; Institut National de la Santé et de la Recherche Médicale; Fondation Leducq; Exzellenzclusters Entzündungsforschung; University of Oxford; Erasmus Medisch Centrum; University of Leeds; Deutsche Forschungsgemeinschaft; University of Ottawa; Deutsches Zentrum für Herz-Kreislaufforschung; Imperial College London; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Helsingin Yliopisto; European Commission; Sanofi; Wellcome Trust; Eli Lilly and Company; Itä-Suomen Yliopisto; Kaiser Permanente; Novo Nordisk; Université de Strasbourg; Università degli Studi di Milano-Bicocca; Pfizer; National Heart and Lung Institute; Institute of Genetics; AstraZeneca; Johannes Gutenberg-Universität Mainz; Bristol-Myers Squibb","keywords":"Glatiramer acetate; Linkage disequilibrium; Single-nucleotide polymorphism; Genome-wide association study; SNP; Genetics; Biology; Odds ratio; Coronary artery disease; Locus (genetics); Bioinformatics; Genetic association; Gene; Multiple sclerosis; Medicine; Internal medicine; Genotype; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004522202,0.0004605396,0.0004914173,0.0009152239,0.0002591264,0.0006347958,0.0003932939,0.000557181,0.002618386],"category_scores_gemma":[0.001668267,0.0002273822,0.001368122,0.001482785,0.0002992044,0.0001452044,0.0003601774,0.0004704594,0.000244553],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00020421,"about_ca_system_score_gemma":0.0002130659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002663114,"about_ca_topic_score_gemma":0.002127936,"domain_scores_codex":[0.9994656,0.0001531316,0.00003962925,0.0002050412,0.00007404701,0.00006249946],"domain_scores_gemma":[0.9988458,0.0004931658,0.0003959291,0.0001267857,0.00004924183,0.00008897542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003736637,0.0001399349,0.922847,0.0002424968,0.004527557,0.002063716,0.0002249489,0.0009238673,0.04924006,0.0004143605,0.0004290709,0.01521039],"study_design_scores_gemma":[0.0000883535,0.0001966796,0.9932716,0.00001943834,0.001844146,0.000802124,0.00005560987,0.0009815792,0.002008728,0.0003052043,0.0004171459,0.000009371833],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953015,0.00252676,0.001029058,0.0001806413,0.00001656066,0.000008885799,0.0004970828,0.00003334939,0.0004059832],"genre_scores_gemma":[0.9984356,0.0004710622,0.0005306419,0.00005438057,0.00002581305,0.000007395958,0.0002829884,0.000007445042,0.000184741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002663114,"threshold_uncertainty_score":0.00875932,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02287978206399622,"score_gpt":0.2179362679365855,"score_spread":0.1950564858725893,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}