{"id":"W2748885995","doi":"10.1093/jmcb/mjx031","title":"Pak1 mediates the stimulatory effect of insulin and curcumin on hepatic ChREBP expression","year":2017,"lang":"en","type":"article","venue":"Journal of Molecular Cell Biology","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; University of Toronto; University Health Network","funders":"Banting and Best Diabetes Centre, University of Toronto; National Cancer Institute; National Institutes of Health; Canadian Institutes of Health Research; Sun Yat-sen University; National Natural Science Foundation of China; University Health Network","keywords":"Carbohydrate-responsive element-binding protein; Curcumin; PAK1; Insulin; Protein kinase B; MAPK/ERK pathway; Insulin receptor; Kinase; Chemistry; Signal transduction; Cell biology; Internal medicine; Biology; Endocrinology; Biochemistry; Transcription factor; Medicine; Insulin resistance; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009602263,0.0004565676,0.000247812,0.0002683065,0.000227161,0.0002446717,0.0001537735,0.0002038065,0.003310233],"category_scores_gemma":[0.00009911907,0.0002019227,0.0004758593,0.0001468359,0.0002184504,0.0003486086,0.0002908691,0.0006114671,0.000803822],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002969698,"about_ca_system_score_gemma":0.0003182146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004529542,"about_ca_topic_score_gemma":0.000947963,"domain_scores_codex":[0.99992,0.00001438314,0.000004829146,0.00001579799,0.00001183445,0.00003308133],"domain_scores_gemma":[0.9999411,0.000008704203,0.00001518327,0.000005294936,0.000008331644,0.00002142575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00112533,0.0001048219,0.0005037981,0.000270325,0.00001876297,0.0001684455,0.00002567577,0.0001068246,0.9931037,0.0003886511,0.0002356472,0.003947962],"study_design_scores_gemma":[0.0001523093,0.0006011844,0.02657068,0.00003227474,0.0000784662,0.0007428609,0.0001194093,0.001778157,0.9630206,0.0006400921,0.00624753,0.00001647882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9753098,0.009229005,0.006723803,0.0007736019,0.0001152985,0.00005273965,0.00064794,0.0001499011,0.006997808],"genre_scores_gemma":[0.9854418,0.005149063,0.002474306,0.000137391,0.00003263611,0.00009073829,0.0006647188,0.00003796065,0.005971305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003310233,"threshold_uncertainty_score":0.01107383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008214264099833059,"score_gpt":0.2749461165129535,"score_spread":0.2667318524131205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}