{"id":"W2748894834","doi":"10.1074/jbc.m117.806638","title":"The Rev1 interacting region (RIR) motif in the scaffold protein XRCC1 mediates a low-affinity interaction with polynucleotide kinase/phosphatase (PNKP) during DNA single-strand break repair","year":2017,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agriculture Food and Rural Development","funders":"Medical Research Council; Canadian Institutes of Health Research","keywords":"XRCC1; Biology; DNA repair; Base excision repair; DNA; Phosphorylation; Cell biology; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002407845,0.0005386932,0.0002793063,0.0001274457,0.0001881435,0.0002826667,0.0003929641,0.0003410983,0.001100734],"category_scores_gemma":[0.0001784284,0.0001842394,0.0003305603,0.00007547875,0.0002552005,0.0003080839,0.0003590747,0.0005090563,0.0006188526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004886795,"about_ca_system_score_gemma":0.0001576569,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003912148,"about_ca_topic_score_gemma":0.0006355401,"domain_scores_codex":[0.9997436,0.00004724494,0.00001539995,0.00008734832,0.00005122089,0.00005510671],"domain_scores_gemma":[0.9998916,0.00001913184,0.00004264178,0.00001107801,0.00001038014,0.00002508347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006243391,0.00001949382,0.0002675391,0.00003335339,0.000005315209,0.00005511003,0.000008009883,0.00005963631,0.9985537,0.0001274222,0.00002449895,0.000783431],"study_design_scores_gemma":[0.00002071907,0.0001674217,0.006265228,0.000005020518,0.00001166206,0.0004805756,0.00001609797,0.002147354,0.9890628,0.00005481017,0.001760273,0.000007887003],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9876747,0.002232405,0.008770216,0.0001038889,0.00001906557,0.00003103526,0.00008981848,0.0001203459,0.0009583657],"genre_scores_gemma":[0.994896,0.0004022517,0.003073542,0.00003121027,0.000007879402,0.00001934301,0.0001995933,0.000012427,0.001357738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001100734,"threshold_uncertainty_score":0.003682375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01866656010015683,"score_gpt":0.2465884292468314,"score_spread":0.2279218691466746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}