{"id":"W2749027583","doi":"10.1111/hae.13324","title":"Pharmacokinetics, safety and efficacy of a recombinant factor <scp>IX</scp> product, trenonacog alfa in previously treated haemophilia B patients","year":2017,"lang":"en","type":"article","venue":"Haemophilia","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Emergent BioSolutions (Canada)","funders":"Grifols; Swedish Orphan Biovitrum; Baxalta; CSL Behring; Biogen; Pfizer","keywords":"Medicine; Haemophilia B; Haemophilia; Adverse effect; Haemophilia A; Pharmacokinetics; Interquartile range; Factor IX; Pharmacodynamics; Bleed; Internal medicine; Gastroenterology; Surgery; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004076343,0.0005148741,0.001112138,0.0004055138,0.0003072197,0.000066202,0.0004248015,0.0002100928,0.00009739443],"category_scores_gemma":[0.001625988,0.0003981618,0.0002050994,0.0002739939,0.0005356887,0.0002300887,0.0002900402,0.0004826269,0.00005653689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001861455,"about_ca_system_score_gemma":0.0001755888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003447391,"about_ca_topic_score_gemma":0.00006196241,"domain_scores_codex":[0.9965175,0.0001512255,0.0008600291,0.0009193223,0.0006795283,0.0008723673],"domain_scores_gemma":[0.9972565,0.0002617114,0.0003881879,0.001281765,0.0003224484,0.0004894306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009927904,0.003021737,0.8482157,0.0006085097,0.0003086345,0.0003416864,0.001491196,0.000001987294,0.004207094,0.00002998826,0.00242281,0.1383579],"study_design_scores_gemma":[0.01637255,0.001239374,0.9531702,0.0005903058,0.0002149752,0.00003316124,0.00003497985,0.0001508109,0.01980057,0.0001088347,0.008098139,0.0001860747],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910942,0.0011543,9.965742e-7,0.00124633,0.0004136231,0.002631716,0.00008638071,0.00006483889,0.003307572],"genre_scores_gemma":[0.9871693,0.002689577,0.0001402476,0.00004689307,0.0001826382,0.00004618966,0.0001749218,0.00007773222,0.009472527],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1381718,"threshold_uncertainty_score":0.9998471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03324998706225211,"score_gpt":0.3179417365716719,"score_spread":0.2846917495094197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}