{"id":"W2749027583","doi":"10.1111/hae.13324","title":"Pharmacokinetics, safety and efficacy of a recombinant factor <scp>IX</scp> product, trenonacog alfa in previously treated haemophilia B patients","year":2017,"lang":"en","type":"article","venue":"Haemophilia","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Emergent BioSolutions (Canada)","funders":"Grifols; Swedish Orphan Biovitrum; Baxalta; CSL Behring; Biogen; Pfizer","keywords":"Medicine; Haemophilia B; Haemophilia; Adverse effect; Haemophilia A; Pharmacokinetics; Interquartile range; Factor IX; Pharmacodynamics; Bleed; Internal medicine; Gastroenterology; Surgery; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005592044,0.0002063737,0.0003537902,0.0001153937,0.0001076081,0.000350962,0.0001229212,0.0002721097,0.0009346579],"category_scores_gemma":[0.001053349,0.0001273025,0.0001939681,0.0001344591,0.0001704713,0.000176634,0.00008231194,0.0003869523,0.000203597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003731622,"about_ca_system_score_gemma":0.0001681718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005077002,"about_ca_topic_score_gemma":0.0004559194,"domain_scores_codex":[0.9997519,0.00009989044,0.00001660467,0.00005389821,0.00005573591,0.00002195669],"domain_scores_gemma":[0.9995596,0.0001035915,0.000199216,0.00002165979,0.00002157372,0.00009439338],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1993214,0.006379246,0.306376,0.0008470223,0.001589059,0.001608099,0.001069132,0.003992818,0.2384205,0.0003029595,0.00207534,0.2380183],"study_design_scores_gemma":[0.01149234,0.2527955,0.7035408,0.00007390825,0.00062479,0.004667744,0.0001360876,0.002490412,0.01969461,0.00008126095,0.004362422,0.00004021209],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985795,0.001033311,0.00007831789,0.00002263107,0.000003022816,0.00002056391,0.00005572542,0.000006436134,0.0002005848],"genre_scores_gemma":[0.9993818,0.0001880195,0.00008591398,0.00002953332,0.000008902413,0.00001537197,0.0001198247,0.000001764941,0.0001688446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009346579,"threshold_uncertainty_score":0.00312674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03324998706225211,"score_gpt":0.3179417365716719,"score_spread":0.2846917495094197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}