{"id":"W2749073211","doi":"10.1182/blood.v128.22.175.175","title":"Randomized Study of Pegasparagase (SS-PEG) and Calaspargase Pegol (SC-PEG) in Pediatric Patients with Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma: Results of DFCI ALL Consortium Protocol 11-001","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Acute Lymphoblastic Leukemia research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Hamilton Health Sciences; Centre hospitalier universitaire de Québec; Université de Montréal; McMaster Children's Hospital","funders":"","keywords":"Medicine; Asparaginase; PEG ratio; Lymphoblastic lymphoma; Gastroenterology; Internal medicine; Pharmacology; Surgery; Leukemia; Lymphoblastic Leukemia; Immunology; T cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004110345,0.001549083,0.00252981,0.0004111342,0.0004551976,0.0013335,0.001267166,0.001760995,0.007787924],"category_scores_gemma":[0.004243942,0.0007207086,0.00194437,0.0006151508,0.001089664,0.001082837,0.0008027947,0.003575111,0.001139417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002557795,"about_ca_system_score_gemma":0.004366383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002003489,"about_ca_topic_score_gemma":0.004741375,"domain_scores_codex":[0.9981081,0.001155047,0.000106185,0.0002265296,0.0001388147,0.0002652663],"domain_scores_gemma":[0.997268,0.0006108569,0.0005763082,0.0001928133,0.0001827244,0.001169264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9796613,0.006340312,0.001656005,0.0001960048,0.0005545034,0.00002822148,0.00003539743,0.000298061,0.0008413133,0.0001472565,0.001098145,0.009143415],"study_design_scores_gemma":[0.8726709,0.1199174,0.003767673,0.00003630734,0.0005333552,0.00003386315,0.00002567295,0.0003131733,0.0002961358,0.0001640946,0.002227551,0.00001379518],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9613593,0.003680688,0.0009669276,0.001402877,0.0005726881,0.02289572,0.004309719,0.0001669611,0.004645103],"genre_scores_gemma":[0.959091,0.001918482,0.002812088,0.002179392,0.0004062443,0.02492095,0.004309119,0.00004930286,0.004313471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007787924,"threshold_uncertainty_score":0.02605319,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01279503569065933,"score_gpt":0.2740441363747799,"score_spread":0.2612491006841206,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}